M K Rimvall1, L Clemmensen1, A Munkholm1, C U Rask2, J T Larsen3, A M Skovgaard4, C J P Simons5, J van Os5, P Jeppesen1. 1. Child and Adolescent Mental Health Center,Mental Health Services,The Capital Region of Denmark,Glostrup,Denmark. 2. Child and Adolescent Psychiatric Centre Risskov,Aarhus University Hospital,Aarhus,Denmark. 3. The National Centre for Register-based Research,Aarhus University,Aarhus,Denmark. 4. Department of Public Health,University of Copenhagen,Copenhagen,Denmark. 5. Department of Psychiatry and Psychology,Maastricht University Medical Centre,Maastricht,The Netherlands.
Abstract
BACKGROUND: Auditory verbal hallucinations (AVH) are common during development and may arise due to dysregulation in top-down processing of sensory input. This study was designed to examine the frequency and correlates of speech illusions measured using the White Noise (WN) task in children from the general population. Associations between speech illusions and putative risk factors for psychotic disorder and negative affect were examined. METHOD: A total of 1486 children aged 11-12 years of the Copenhagen Child Cohort 2000 were examined with the WN task. Psychotic experiences and negative affect were determined using the Kiddie-SADS-PL. Register data described family history of mental disorders. Exaggerated Theory of Mind functioning (hyper-ToM) was measured by the ToM Storybook Frederik. RESULTS: A total of 145 (10%) children experienced speech illusions (hearing speech in the absence of speech stimuli), of which 102 (70%) experienced illusions perceived by the child as positive or negative (affectively salient). Experiencing hallucinations during the last month was associated with affectively salient speech illusions in the WN task [general cognitive ability: adjusted odds ratio (aOR) 2.01, 95% confidence interval (CI) 1.03-3.93]. Negative affect, both last month and lifetime, was also associated with affectively salient speech illusions (aOR 2.01, 95% CI 1.05-3.83 and aOR 1.79, 95% CI 1.11-2.89, respectively). Speech illusions were not associated with delusions, hyper-ToM or family history of mental disorders. CONCLUSIONS: Speech illusions were elicited in typically developing children in a WN-test paradigm, and point to an affective pathway to AVH mediated by dysregulation in top-down processing of sensory input.
BACKGROUND:Auditory verbal hallucinations (AVH) are common during development and may arise due to dysregulation in top-down processing of sensory input. This study was designed to examine the frequency and correlates of speech illusions measured using the White Noise (WN) task in children from the general population. Associations between speech illusions and putative risk factors for psychotic disorder and negative affect were examined. METHOD: A total of 1486 children aged 11-12 years of the Copenhagen Child Cohort 2000 were examined with the WN task. Psychotic experiences and negative affect were determined using the Kiddie-SADS-PL. Register data described family history of mental disorders. Exaggerated Theory of Mind functioning (hyper-ToM) was measured by the ToM Storybook Frederik. RESULTS: A total of 145 (10%) children experienced speech illusions (hearing speech in the absence of speech stimuli), of which 102 (70%) experienced illusions perceived by the child as positive or negative (affectively salient). Experiencing hallucinations during the last month was associated with affectively salient speech illusions in the WN task [general cognitive ability: adjusted odds ratio (aOR) 2.01, 95% confidence interval (CI) 1.03-3.93]. Negative affect, both last month and lifetime, was also associated with affectively salient speech illusions (aOR 2.01, 95% CI 1.05-3.83 and aOR 1.79, 95% CI 1.11-2.89, respectively). Speech illusions were not associated with delusions, hyper-ToM or family history of mental disorders. CONCLUSIONS: Speech illusions were elicited in typically developing children in a WN-test paradigm, and point to an affective pathway to AVH mediated by dysregulation in top-down processing of sensory input.
Authors: Lotta-Katrin Pries; Sinan Guloksuz; Claudia Menne-Lothmann; Jeroen Decoster; Ruud van Winkel; Dina Collip; Philippe Delespaul; Marc De Hert; Catherine Derom; Evert Thiery; Nele Jacobs; Marieke Wichers; Claudia J P Simons; Bart P F Rutten; Jim van Os Journal: PLoS One Date: 2017-08-23 Impact factor: 3.240
Authors: Maider Gonzalez de Artaza; Ana Catalan; Virxinia Angosto; Cristina Valverde; Amaia Bilbao; Jim van Os; Miguel Angel Gonzalez-Torres Journal: PLoS One Date: 2018-02-15 Impact factor: 3.240
Authors: Elaine Schepers; Richel Lousberg; Sinan Guloksuz; Lotta-Katrin Pries; Philippe Delespaul; Gunter Kenis; Jurjen J Luykx; Bochao D Lin; Alexander L Richards; Berna Akdede; Tolga Binbay; Vesile Altınyazar; Berna Yalınçetin; Güvem Gümüş-Akay; Burçin Cihan; Haldun Soygür; Halis Ulaş; Eylem Şahin Cankurtaran; Semra Ulusoy Kaymak; Marina M Mihaljevic; Sanja Andric Petrovic; Tijana Mirjanic; Miguel Bernardo; Bibiana Cabrera; Julio Bobes; Pilar A Saiz; María Paz García-Portilla; Julio Sanjuan; Eduardo J Aguilar; José Luis Santos; Estela Jiménez-López; Manuel Arrojo; Angel Carracedo; Gonzalo López; Javier González-Peñas; Mara Parellada; Nadja P Maric; Cem Atbaşoğlu; Alp Ucok; Köksal Alptekin; Meram Can Saka; Celso Arango; Bart P F Rutten; Jim van Os Journal: Front Psychiatry Date: 2019-09-25 Impact factor: 4.157
Authors: Anne Amalie Elgaard Thorup; Nicoline Hemager; Vibeke Fuglsang Bliksted; Aja Neergaard Greve; Jessica Ohland; Martin Wilms; Sinnika Birkehøj Rohd; Merete Birk; Anette Faurskov Bundgaard; Andreas Færgemand Laursen; Oskar Hougaard Jefsen; Nanna Lawaetz Steffensen; Anna Krogh Andreassen; Lotte Veddum; Christina Bruun Knudsen; Mette Enevoldsen; Marie Nymand; Julie Marie Brandt; Anne Søndergaard; Line Carmichael; Maja Gregersen; Mette Falkenberg Krantz; Birgitte Klee Burton; Martin Dietz; Ron Nudel; Line Korsgaard Johnsen; Kit Melissa Larsen; David Meder; Oliver James Hulme; William Frans Christiaan Baaré; Kathrine Skak Madsen; Torben Ellegaard Lund; Leif Østergaard; Anders Juul; Troels Wesenberg Kjær; Carsten Hjorthøj; Hartwig Roman Siebner; Ole Mors; Merete Nordentoft Journal: Front Psychiatry Date: 2022-04-04 Impact factor: 5.435