Literature DB >> 27444625

[Association between bone catabolism and anti-citrullinated protein antibodies in rheumatoid arthritis].

U Harre1, G Schett2.   

Abstract

Anti-citrullinated protein antibodies (ACPA) are highly specific for rheumatoid arthritis and according to the ACR-EULAR 2010 guidelines represent an important serological marker for the diagnosis of the disease. Patients with rheumatoid arthritis who are positive for ACPA display more severe bone erosion and have an overall poorer prognosis in progression of the disease compared to ACPA negative patients. For a long time it was unknown how ACPA exactly affect bone homeostasis. In this article, recent findings about the mechanisms by which ACPA contribute to bone loss are discussed.

Entities:  

Keywords:  Bone loss; Marker; Osteoclast; Prognosis; Progression

Mesh：

Substances：

Year:  2016        PMID： 27444625     DOI： 10.1007/s00393-016-0149-4

Source DB:  PubMed          Journal:  Z Rheumatol        ISSN： 0340-1855            Impact factor:   1.372


  10 in total

Review 1.  The pathogenesis of rheumatoid arthritis.

Authors:  Iain B McInnes; Georg Schett
Journal:  N Engl J Med       Date:  2011-12-08       Impact factor: 91.245

Review 2.  The role of sialic acid as a modulator of the anti-inflammatory activity of IgG.

Authors:  Sybille Böhm; Inessa Schwab; Anja Lux; Falk Nimmerjahn
Journal:  Semin Immunopathol       Date:  2012-03-22       Impact factor: 9.623

3.  Glycan profiling of anti-citrullinated protein antibodies isolated from human serum and synovial fluid.

Authors:  Hans U Scherer; Diane van der Woude; Andreea Ioan-Facsinay; Hanane el Bannoudi; Leendert A Trouw; Jun Wang; Thomas Häupl; Gerd-R Burmester; André M Deelder; Tom W J Huizinga; Manfred Wuhrer; René E M Toes
Journal:  Arthritis Rheum       Date:  2010-06

4.  Separately tackling the development of erosions with denosumab: ultimately closing a gap in the treatment of patients with rheumatoid arthritis or trying too hard too late?

Authors:  P Verschueren; R Westhovens
Journal:  Ann Rheum Dis       Date:  2016-02-09       Impact factor: 19.103

5.  Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin.

Authors:  Ulrike Harre; Dan Georgess; Holger Bang; Aline Bozec; Roland Axmann; Elena Ossipova; Per-Johan Jakobsson; Wolfgang Baum; Falk Nimmerjahn; Eszter Szarka; Gabriella Sarmay; Grit Krumbholz; Elena Neumann; Rene Toes; Hans-Ulrich Scherer; Anca Irinel Catrina; Lars Klareskog; Pierre Jurdic; Georg Schett
Journal:  J Clin Invest       Date:  2012-04-16       Impact factor: 14.808

Review 6.  Update on autoantibodies to modified proteins.

Authors:  René E M Toes; Tom J W Huizinga
Journal:  Curr Opin Rheumatol       Date:  2015-05       Impact factor: 5.006

7.  Bone loss before the clinical onset of rheumatoid arthritis in subjects with anticitrullinated protein antibodies.

Authors:  Arnd Kleyer; Stephanie Finzel; Jürgen Rech; Bernhard Manger; Manuel Krieter; Francesca Faustini; Elisabeth Araujo; Axel J Hueber; Ulrike Harre; Klaus Engelke; Georg Schett
Journal:  Ann Rheum Dis       Date:  2013-03-21       Impact factor: 19.103

8.  Inflammatory monocytes and Fcγ receptor IV on osteoclasts are critical for bone destruction during inflammatory arthritis in mice.

Authors:  Michaela Seeling; Ulrike Hillenhoff; Jean Pierre David; Georg Schett; Jan Tuckermann; Anja Lux; Falk Nimmerjahn
Journal:  Proc Natl Acad Sci U S A       Date:  2013-06-10       Impact factor: 11.205

9.  Glycosylation of immunoglobulin G determines osteoclast differentiation and bone loss.

Authors:  Ulrike Harre; Stefanie C Lang; René Pfeifle; Yoann Rombouts; Sabine Frühbeißer; Khaled Amara; Holger Bang; Anja Lux; Carolien A Koeleman; Wolfgang Baum; Katharina Dietel; Franziska Gröhn; Vivianne Malmström; Lars Klareskog; Gerhard Krönke; Roland Kocijan; Falk Nimmerjahn; René E M Toes; Martin Herrmann; Hans Ulrich Scherer; Georg Schett
Journal:  Nat Commun       Date:  2015-03-31       Impact factor: 14.919

10.  Identification of a novel chemokine-dependent molecular mechanism underlying rheumatoid arthritis-associated autoantibody-mediated bone loss.

Authors:  Akilan Krishnamurthy; Vijay Joshua; Aase Haj Hensvold; Tao Jin; Meng Sun; Nancy Vivar; A Jimmy Ytterberg; Marianne Engström; Cátia Fernandes-Cerqueira; Khaled Amara; Malin Magnusson; Gustaf Wigerblad; Jungo Kato; Juan Miguel Jiménez-Andrade; Kerry Tyson; Stephen Rapecki; Karin Lundberg; Sergiu-Bogdan Catrina; Per-Johan Jakobsson; Camilla Svensson; Vivianne Malmström; Lars Klareskog; Heidi Wähämaa; Anca I Catrina
Journal:  Ann Rheum Dis       Date:  2015-11-26       Impact factor: 19.103
  10 in total

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