Literature DB >> 2744331

Lithocholate in liver tissue with obstructive jaundice.

J Yanagisawa1, M Nagai, Y Hirano, T Fujii, F Nakayama.   

Abstract

The existence of tissue-bound lithocholate in liver tissue was first suggested by Nair et al. (Lipids 1988;12:922-929). Since lithocholate is well known to be cholestatic, we investigated whether tissue-bound lithocholate, if present, can be correlated to liver dysfunction in obstructive jaundice. Tissue-bound lithocholate in liver tissues of 7 patients with obstructive jaundice was analyzed using gas chromatography-mass spectrometry-selected ion monitoring. We found no accumulation of lithocholate, including tissue-bound form, indicating that the role of lithocholate in inducing hepatic dysfunction in obstructive jaundice is minimal, if any.

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Year:  1989        PMID： 2744331     DOI： 10.1007/bf02774190

Source DB:  PubMed          Journal:  Gastroenterol Jpn        ISSN： 0435-1339


  11 in total

1.  Bile acid metabolism in mammals. I. Bile acid-induced intrahepatic cholestasis.

Authors:  M M Fisher; R Magnusson; K Miyai
Journal:  Lab Invest       Date:  1971-07       Impact factor: 5.662

2.  Mechanism of cholic acid protection in lithocholate-induced intrahepatic cholestasis in rats.

Authors:  G Kakis; I M Yousef
Journal:  Gastroenterology       Date:  1980-06       Impact factor: 22.682

3.  Microanalysis of bile acid in human liver tissue by selected ion monitoring.

Authors:  J Yanagisawa; M Itoh; M Ishibashi; H Miyazaki; F Nakayama
Journal:  Anal Biochem       Date:  1980-05-01       Impact factor: 3.365

4.  Monohydroxy bile salt sulfates: tauro-3 beta-hydroxy-5-cholenoate-3-sulfate induces intrahepatic cholestasis in rats.

Authors:  U Mathis; G Karlaganis; R Preisig
Journal:  Gastroenterology       Date:  1983-09       Impact factor: 22.682

5.  Subcellular pathology of rat liver in cholestasis and choleresis induced by bile salts. 1. Effects of lithocholic, 3beta-hydroxy-5-cholenoic, cholic, and dehydrocholic acids.

Authors:  K Miyai; A L Richardson; W Mayr; N B Javitt
Journal:  Lab Invest       Date:  1977-03       Impact factor: 5.662

6.  Bile acids in tissues: binding of lithocholic acid to protein.

Authors:  P P Nair; R Solomon; J Bankoski; R Plapinger
Journal:  Lipids       Date:  1978-12       Impact factor: 1.880

7.  Correlation of bile acid composition between liver tissue and bile.

Authors:  Y Akashi; H Miyazaki; F Nakayama
Journal:  Clin Chim Acta       Date:  1983-09-30       Impact factor: 3.786

8.  Lithocholate glucuronide is a cholestatic agent.

Authors:  D G Oelberg; M V Chari; J M Little; E W Adcock; R Lester
Journal:  J Clin Invest       Date:  1984-06       Impact factor: 14.808

9.  Nature of tissue-bound lithocholic acid and its implications in the role of bile acids in carcinogenesis.

Authors:  N Turjman; P P Nair
Journal:  Cancer Res       Date:  1981-09       Impact factor: 12.701

10.  Critical evaluation of the existence of so-called tissue-bound lithocholate in human liver tissue by selected ion monitoring.

Authors:  J Yanagisawa; Y Akashi; H Miyazaki; F Nakayama
Journal:  J Lipid Res       Date:  1984-11       Impact factor: 5.922
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  1 in total

1.  Profiling circulating and urinary bile acids in patients with biliary obstruction before and after biliary stenting.

Authors:  Jocelyn Trottier; Andrzej Białek; Patrick Caron; Robert J Straka; Piotr Milkiewicz; Olivier Barbier
Journal:  PLoS One       Date:  2011-07-08       Impact factor: 3.240
  1 in total

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