Bruce P Hermann1, Qianqian Zhao2, Daren C Jackson3, Jana E Jones3, Kevin Dabbs3, Dace Almane3, David A Hsu3, Carl E Stafstrom4, Monica A Koehn5, Michael Seidenberg6, Paul J Rathouz2. 1. Department of Neurology, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States. Electronic address: hermann@neurology.wisc.edu. 2. Department of Biostatistics and Medical Informatics, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States. 3. Department of Neurology, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States. 4. Department of Neurology, Johns Hopkins University, Baltimore, MD, United States. 5. Neuroscience Department, Marshfield Clinic, Marshfield, WI, United States. 6. Department of Psychology, Rosalind Franklin University of Health Sciences, North Chicago, IL, United States.
Abstract
OBJECTIVE: The objective of this study was to identify cognitive phenotypes in children with new-onset focal and generalized idiopathic epilepsies and determine their relationship with epilepsy syndrome, brain structure, neurodevelopmental history, and family characteristics. METHODS: One hundred thirty-eight children with new-onset epilepsy and 95 controls (age: 8-18) underwent neuropsychological, clinical, and quantitative MR evaluations. Control participants' neuropsychological data were subjected to confirmatory factor analysis and then resultant factor scores were applied to participants with epilepsy and subjected to latent class analysis. Identified cognitive phenotypes were examined in relation to epilepsy syndrome, quantitative neuroimaging, and familial and neurodevelopmental variables. RESULTS: Confirmatory factor analysis identified five cognitive factors (verbal, perceptual, speed, attention, executive), and latent class analysis identified three clusters of participants with epilepsy: 1) average and similar to controls, 2) mild impairment across multiple cognitive domains, and 3) impairment across all domains with severe attentional impairment, representing 44%, 44%, and 12% of the epilepsy sample, respectively. Cognitive phenotype membership was not associated with epilepsy syndrome but was associated with increasing abnormalities in brain structure, parental IQ, and features of early developmental history. SIGNIFICANCE: Cognitive phenotypes are present in idiopathic childhood epilepsies that are unassociated with traditional epilepsy syndromes but are associated with measures of brain structure, family history, and neurodevelopmental features.
OBJECTIVE: The objective of this study was to identify cognitive phenotypes in children with new-onset focal and generalized idiopathic epilepsies and determine their relationship with epilepsy syndrome, brain structure, neurodevelopmental history, and family characteristics. METHODS: One hundred thirty-eight children with new-onset epilepsy and 95 controls (age: 8-18) underwent neuropsychological, clinical, and quantitative MR evaluations. Control participants' neuropsychological data were subjected to confirmatory factor analysis and then resultant factor scores were applied to participants with epilepsy and subjected to latent class analysis. Identified cognitive phenotypes were examined in relation to epilepsy syndrome, quantitative neuroimaging, and familial and neurodevelopmental variables. RESULTS: Confirmatory factor analysis identified five cognitive factors (verbal, perceptual, speed, attention, executive), and latent class analysis identified three clusters of participants with epilepsy: 1) average and similar to controls, 2) mild impairment across multiple cognitive domains, and 3) impairment across all domains with severe attentional impairment, representing 44%, 44%, and 12% of the epilepsy sample, respectively. Cognitive phenotype membership was not associated with epilepsy syndrome but was associated with increasing abnormalities in brain structure, parental IQ, and features of early developmental history. SIGNIFICANCE: Cognitive phenotypes are present in idiopathic childhood epilepsies that are unassociated with traditional epilepsy syndromes but are associated with measures of brain structure, family history, and neurodevelopmental features.
Authors: Kevin Dabbs; Tara Becker; Jana Jones; Paul Rutecki; Michael Seidenberg; Bruce Hermann Journal: Epilepsia Date: 2012-04-03 Impact factor: 5.864
Authors: Melinda A Nolan; M Antoinette Redoblado; Suncica Lah; Mark Sabaz; John A Lawson; Anne M Cunningham; Andrew F Bleasel; Ann M E Bye Journal: Epilepsy Res Date: 2003-02 Impact factor: 3.045
Authors: Kim J Oostrom; Anneke Smeets-Schouten; Cas L J J Kruitwagen; A C Boudewyn Peters; Aagje Jennekens-Schinkel Journal: Pediatrics Date: 2003-12 Impact factor: 7.124
Authors: Daren C Jackson; Kevin Dabbs; Natalie M Walker; Jana E Jones; David A Hsu; Carl E Stafstrom; Michael Seidenberg; Bruce P Hermann Journal: J Pediatr Date: 2012-12-05 Impact factor: 4.406
Authors: Dace N Almane; Jana E Jones; Taylor McMillan; Carl E Stafstrom; David A Hsu; Michael Seidenberg; Bruce P Hermann; Temitayo O Oyegbile Journal: Pediatr Neurol Date: 2019-03-19 Impact factor: 3.372
Authors: Bruce P Hermann; Aaron F Struck; Robyn M Busch; Anny Reyes; Erik Kaestner; Carrie R McDonald Journal: Nat Rev Neurol Date: 2021-09-22 Impact factor: 44.711
Authors: Bruce P Hermann; Aaron F Struck; Carl E Stafstrom; David A Hsu; Kevin Dabbs; Carson Gundlach; Dace Almane; Michael Seidenberg; Jana E Jones Journal: Epilepsia Date: 2020-06-18 Impact factor: 5.864
Authors: Camille Garcia-Ramos; Kevin Dabbs; Elizabeth Meyerand; Vivek Prabhakaran; David Hsu; Jana Jones; Michael Seidenberg; Bruce Hermann Journal: Neuroimage Clin Date: 2018-04-20 Impact factor: 4.881