Minal Kumari1, Santosh S Martande2, A R Pradeep3, Savitha B Naik4. 1. Department of Periodontics, Vydehi Institute of Dental Sciences and Research Centre, Bangalore, India. 2. Department of Periodontics, Dr. D.Y. Patil Dental College and Hospital, Pune, India. 3. Department of Periodontics, Government Dental College and Research Institute, Bangalore, India. 4. Department of Conservative Dentistry and Endodontics, Government Dental College and Research Institute.
Abstract
BACKGROUND: The present study was designed to evaluate effectiveness of 1.2% atorvastatin (ATV) gel, as an adjunct to scaling and root planing (SRP) in the treatment of intrabony defects in chronic periodontitis (CP) in patients with type 2 diabetes mellitus (t2DM). METHODS:Seventy-five patients were categorized into two treatment groups: 1) SRP plus 1.2% ATV and 2) SRP plus placebo. Clinical parameters including modified sulcus bleeding index, probing depth (PD), and relative attachment level (RAL) were recorded at baseline and 3, 6, and 9 months. Percentage radiographic defect depth reduction was evaluated using computer-aided software at baseline and 6 and 9 months. RESULTS:Mean PD reduction and mean RAL gain was greater in the ATV group than the placebo group at 3, 6, and 9 months. Furthermore, ATV group sites presented with a significantly greater percentage of radiographic defect depth reduction at 6 and 9 months. CONCLUSION: Locally delivered ATV was found to be effective in treatment of intrabony defects in CP in patients with t2DM.
RCT Entities:
BACKGROUND: The present study was designed to evaluate effectiveness of 1.2% atorvastatin (ATV) gel, as an adjunct to scaling and root planing (SRP) in the treatment of intrabony defects in chronic periodontitis (CP) in patients with type 2 diabetes mellitus (t2DM). METHODS: Seventy-five patients were categorized into two treatment groups: 1) SRP plus 1.2% ATV and 2) SRP plus placebo. Clinical parameters including modified sulcus bleeding index, probing depth (PD), and relative attachment level (RAL) were recorded at baseline and 3, 6, and 9 months. Percentage radiographic defect depth reduction was evaluated using computer-aided software at baseline and 6 and 9 months. RESULTS: Mean PD reduction and mean RAL gain was greater in the ATV group than the placebo group at 3, 6, and 9 months. Furthermore, ATV group sites presented with a significantly greater percentage of radiographic defect depth reduction at 6 and 9 months. CONCLUSION: Locally delivered ATV was found to be effective in treatment of intrabony defects in CP in patients with t2DM.
Authors: Jonathan Meza-Mauricio; David Soto-Peñaloza; David Peñarrocha-Oltra; Jose Maria Montiel-Company; Daiane Cristina Peruzzo Journal: Clin Oral Investig Date: 2018-06-12 Impact factor: 3.573