Literature DB >> 2744110

Individual cells in the raphe nuclei of the medulla oblongata in rat that contain immunoreactivities for both serotonin and enkephalin project to the spinal cord.

D E Millhorn1, T Hökfelt, A A Verhofstad, L Terenius.   

Abstract

The ventral medulla oblongata of rats was analyzed with a double-labelling immunofluorescence technique using guinea pig antibodies directed against serotonin (5-HT) and rabbit antisera directed against enkephalin (ENK). Numerous cells in the region of nucleus raphe obscurus, nucleus raphe pallidus and nucleus raphe magnus showed immunostaining for either 5-HT or ENK. A substantial number of cells showed positive immunostaining for both 5-HT and ENK. 5-HT/ENK double-labelled cells were most frequently encountered in an area that extended from the rostral aspect of the inferior olivary nucleus to the pontomedullary border. This region corresponds anatomically to nucleus raphe magnus/nucleus paragigantocellularis. In addition, a number of the 5-HT/ENK-containing cells were retrogradely labelled with Fluoro-Gold dye that had been injected into the thoracic spinal cord several days prior to perfusion. Schematic drawings showing the anatomical distribution of 5-HT/ENK colocalization are provided.

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Year:  1989        PMID： 2744110     DOI： 10.1007/bf00249904

Source DB:  PubMed          Journal:  Exp Brain Res        ISSN： 0014-4819            Impact factor:   1.972


  41 in total

1.  Fluorescent antibody methods.

Authors:  A H COONS
Journal:  Gen Cytochem Methods       Date:  1958

2.  Serotonergic projections from the ventral medulla to the intermediolateral cell column in the rat.

Authors:  A D Loewy; S McKellar
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Authors:  M M Caverson; J Ciriello; F R Calaresu
Journal:  J Auton Nerv Syst       Date:  1983-11

4.  Retardation of fading and enhancement of intensity of immunofluorescence by p-phenylenediamine.

Authors:  J L Platt; A F Michael
Journal:  J Histochem Cytochem       Date:  1983-06       Impact factor: 2.479

5.  Inhibition of spinothalamic tract cells and interneurons by brain stem stimulation in the monkey.

Authors:  W D Willis; L H Haber; R F Martin
Journal:  J Neurophysiol       Date:  1977-07       Impact factor: 2.714

6.  A simple method of reducing the fading of immunofluorescence during microscopy.

Authors:  G D Johnson; G M Nogueira Araujo
Journal:  J Immunol Methods       Date:  1981       Impact factor: 2.303

7.  Serotonin neurons in nucleus raphe dorsalis and paragigantocellularis of the cat contain enkephalin.

Authors:  E J Glazer; H Steinbusch; A Verhofstad; A I Basbaum
Journal:  J Physiol (Paris)       Date:  1981

8.  The distribution of enkephalin-immunoreactive cell bodies in the rat central nervous system.

Authors:  T Hökfelt; R Elde; O Johansson; L Terenius; L Stein
Journal:  Neurosci Lett       Date:  1977-06       Impact factor: 3.046

9.  The immunocytochemical localization of enkephalin in the central nervous system of the rat.

Authors:  J C Finley; J L Maderdrut; P Petrusz
Journal:  J Comp Neurol       Date:  1981-06-01       Impact factor: 3.215

10.  Coexistence of galanin-like immunoreactivity with catecholamines, 5-hydroxytryptamine, GABA and neuropeptides in the rat CNS.

Authors:  T Melander; T Hökfelt; A Rökaeus; A C Cuello; W H Oertel; A Verhofstad; M Goldstein
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5.  Exercise-induced pain requires NMDA receptor activation in the medullary raphe nuclei.

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6.  Tachykininergic slow depolarization of motoneurones evoked by descending fibres in the neonatal rat spinal cord.

Authors:  T Kurihara; K Yoshioka; M Otsuka
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  8 in total

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