Literature DB >> 27438008

A bactericidal calix[4]arene-based nanoconstruct with amplified NO photorelease.

Ivana Di Bari1, Roberta Picciotto, Giuseppe Granata, Anna R Blanco, Grazia M L Consoli, Salvatore Sortino.   

Abstract

A hydrophobic N-dodecyl-3-(trifluoromethyl)-4-nitrobenzenamine has been synthesized as a suitable NO photodonor and encapsulated in a nanocontainer based on a polycationic calix[4]arene derivative, leading to a supramolecular micellar-like nanoassembly ca. 45 nm in diameter. Visible light excitation of this nanoconstruct triggers NO generation with an efficiency remarkably higher than that observed for the free NO photoreleaser. This amplified NO release results in considerable antibacterial activity against Staphylococcus aureus (ATCC 6538) and Pseudomonas aeruginosa (ATCC 9027) as representative Gram positive and Gram negative bacteria, respectively.

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Year:  2016        PMID： 27438008     DOI： 10.1039/c6ob01305h

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  9 in total

1.  S,S-Chiral Linker Induced U Shape with a Syn-facial Sensitizer and Photocleavable Ethene Group.

Authors:  Goutam Ghosh; Sarah J Belh; Callistus Chiemezie; Niluksha Walalawela; Ashwini A Ghogare; Mariana Vignoni; Andrés H Thomas; Sherri A McFarland; Edyta M Greer; Alexander Greer
Journal:  Photochem Photobiol       Date:  2018-09-27       Impact factor: 3.421

2.  Design, Synthesis, and Antibacterial Activity of a Multivalent Polycationic Calix[4]arene-NO Photodonor Conjugate.

Authors:  Grazia M L Consoli; Ivana Di Bari; Anna R Blanco; Antonia Nostro; Manuela D'Arrigo; Venerando Pistarà; Salvatore Sortino
Journal:  ACS Med Chem Lett       Date:  2017-07-05       Impact factor: 4.345

3.  Antibacterial Nanoassembled Calix[4]arene Exposing Choline Units Inhibits Biofilm and Motility of Gram Negative Bacteria.

Authors:  Grazia Maria Letizia Consoli; Giuseppe Granata; Giovanna Ginestra; Andreana Marino; Giovanni Toscano; Antonia Nostro
Journal:  ACS Med Chem Lett       Date:  2022-05-10       Impact factor: 4.632

Review 4.  Nitric Oxide-Releasing Macromolecular Scaffolds for Antibacterial Applications.

Authors:  Lei Yang; Evan S Feura; Mona Jasmine R Ahonen; Mark H Schoenfisch
Journal:  Adv Healthc Mater       Date:  2018-05-14       Impact factor: 9.933

5.  Design, synthesis and antibacterial evaluation of a polycationic calix[4]arene derivative alone and in combination with antibiotics.

Authors:  G M L Consoli; G Granata; R Picciotto; A R Blanco; C Geraci; A Marino; A Nostro
Journal:  Medchemcomm       Date:  2017-12-01       Impact factor: 3.597

6.  A light-induced nitric oxide controllable release nano-platform based on diketopyrrolopyrrole derivatives for pH-responsive photodynamic/photothermal synergistic cancer therapy.

Authors:  Ya Wang; Xiaoyu Huang; Yunyun Tang; Jianhua Zou; Peng Wang; Yewei Zhang; Weili Si; Wei Huang; Xiaochen Dong
Journal:  Chem Sci       Date:  2018-08-29       Impact factor: 9.825

Review 7.  Antimicrobial Activity of Calixarenes and Related Macrocycles.

Authors:  Dmitriy N Shurpik; Pavel L Padnya; Ivan I Stoikov; Peter J Cragg
Journal:  Molecules       Date:  2020-11-05       Impact factor: 4.411

8.  Topical Delivery of Curcumin by Choline-Calix[4]arene-Based Nanohydrogel Improves Its Therapeutic Effect on a Psoriasis Mouse Model.

Authors:  Alessia Filippone; Grazia M L Consoli; Giuseppe Granata; Giovanna Casili; Marika Lanza; Alessio Ardizzone; Salvatore Cuzzocrea; Emanuela Esposito; Irene Paterniti
Journal:  Int J Mol Sci       Date:  2020-07-17       Impact factor: 5.923

9.  Nanoscale lipid vesicles functionalized with a nitro-aniline derivative for photoinduced nitric oxide (NO) delivery.

Authors:  Nancy Sharma; Ajay Kumar Dhyani; Srujan Marepally; D Amilan Jose
Journal:  Nanoscale Adv       Date:  2019-11-20
  9 in total

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