Maxime Mermod1, Massimo Bongiovanni2, Tatiana V Petrova3, Elena A Dubikovskaya4, Christian Simon1, Genrich Tolstonog1, Yan Monnier1. 1. Department of Otolaryngology - Head and Neck Surgery, Head and Neck Tumor Laboratory, CHUV and University of Lausanne, Lausanne, Switzerland. 2. Institute of Pathology, CHUV and University of Lausanne, Lausanne, Switzerland. 3. Department of Fundamental Oncology, CHUV and University of Lausanne, Lausanne, Switzerland. 4. Laboratory of Bioorganic Chemistry and Molecular Imaging (LBCMI), Institute of Chemical Sciences and Engineering (ISIC), École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Abstract
BACKGROUND: The correlation between podoplanin expression and extracapsular spread in head and neck squamous cell carcinoma (HNSCC) has never been reported. The purpose of this study was to assess the predictive value of podoplanin expression for this parameter. METHODS: Subjective immunoreactivity scores and semiquantitative image analysis of podoplanin expression were performed in 67 patients with primary oral squamous cell carcinoma and in their corresponding lymph nodes. Neck classification showed 34 cases (51%) of pN0 and 33 cases (49%) of pN+. Correlation between the levels of podoplanin expression and the histopathological data was established. RESULTS: In lymph nodes, a high level of podoplanin expression correlated with the presence of extracapsular spread by multivariate analysis (p = .03). A strong correlation between subjective and semiquantitative image analysis was observed (r = 0.77; p < .001). CONCLUSION: A high level of podoplanin expression in lymph node metastases of oral squamous cell carcinoma is independently associated with extracapsular spread.
BACKGROUND: The correlation between podoplanin expression and extracapsular spread in head and neck squamous cell carcinoma (HNSCC) has never been reported. The purpose of this study was to assess the predictive value of podoplanin expression for this parameter. METHODS: Subjective immunoreactivity scores and semiquantitative image analysis of podoplanin expression were performed in 67 patients with primary oral squamous cell carcinoma and in their corresponding lymph nodes. Neck classification showed 34 cases (51%) of pN0 and 33 cases (49%) of pN+. Correlation between the levels of podoplanin expression and the histopathological data was established. RESULTS: In lymph nodes, a high level of podoplanin expression correlated with the presence of extracapsular spread by multivariate analysis (p = .03). A strong correlation between subjective and semiquantitative image analysis was observed (r = 0.77; p < .001). CONCLUSION: A high level of podoplanin expression in lymph node metastases of oral squamous cell carcinoma is independently associated with extracapsular spread.
Authors: Marius Otto; Sebastian Blatt; Andreas Pabst; Robert Mandic; Johanna Schwarz; Andreas Neff; Thomas Ziebart Journal: Clin Oral Investig Date: 2019-01-28 Impact factor: 3.573
Authors: Hye Ran Lee; Jin Roh; Ga Young Gu; Ju Ho Lee; Yoo Seob Shin; Jeon Yeob Jang; Chul-Ho Kim Journal: Sci Rep Date: 2022-03-07 Impact factor: 4.379