Fei Zhou1,2, Li Gu3, Jiu Xin Qu3, Ying Mei Liu2, Bin Cao1,2. 1. Beijing Chao-Yang Hospital, Beijing Institute of Respiratory Medicine, Capital Medical University, Beijing, China. 2. Respiratory and Critical Care Medicine 2#, China-Japan Friendship Hospital, Beijing, China. 3. Department of Infectious diseases and Clinical Microbiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Abstract
INTRODUCTION: Binax NOW rapid immunochromatographic membrane test (ICT), a rapid method for detection of Streptococcus pneumoniae antigen, has been used widely in Europe and America, but rarely in China. OBJECTIVE: Our aim is to evaluate the utility of the ICT among adult patients with community acquired pneumonia (CAP) in China. METHODS: Adult patients with CAP were prospectively recruited from 12 general hospitals. ICT tests were done in all patients and clinical data were recorded. Qualified sputum culture was used as the standard for determining the diagnostic usefulness of ICT test. RESULT: Thousand hundred fifty four CAP patients were enrolled in analysis, with median (IQR) age of 48 (35) years. 276 (23.9%) patients had underling diseases, 770 (66.7%) had received antibiotics before ICT test. Overall, the positive rate of ICT test was 3.3%, with sensitivity and specificity 57.9% and 96.6%, respectively. Disease severity, chronic obstructive pulmonary disease (COPD), increased age; respiratory rate (RR), neutrophil ratio, blood urea nitrogen (BUN), procalcitonin (PCT) and the decreased oxygenation index were associated with positive results of ICT tests. Patients with BUN >7 mmol/L, CURB-65 3-5, PCT > 2ng/mL were the top three groups with highest positive rate of ICT test (22.6%, 22.2% and 21.1% respectively). CONCLUSION: ICT test has a moderate sensitivity and high specificity in adults with CAP in China. Patients classified as sever pneumonia, or those with BUN > 7 mmol/L, or PCT > 2 ng/mL are more likely to have positive results.
INTRODUCTION: Binax NOW rapid immunochromatographic membrane test (ICT), a rapid method for detection of Streptococcus pneumoniae antigen, has been used widely in Europe and America, but rarely in China. OBJECTIVE: Our aim is to evaluate the utility of the ICT among adult patients with community acquired pneumonia (CAP) in China. METHODS: Adult patients with CAP were prospectively recruited from 12 general hospitals. ICT tests were done in all patients and clinical data were recorded. Qualified sputum culture was used as the standard for determining the diagnostic usefulness of ICT test. RESULT: Thousand hundred fifty four CAP patients were enrolled in analysis, with median (IQR) age of 48 (35) years. 276 (23.9%) patients had underling diseases, 770 (66.7%) had received antibiotics before ICT test. Overall, the positive rate of ICT test was 3.3%, with sensitivity and specificity 57.9% and 96.6%, respectively. Disease severity, chronic obstructive pulmonary disease (COPD), increased age; respiratory rate (RR), neutrophil ratio, blood ureanitrogen (BUN), procalcitonin (PCT) and the decreased oxygenation index were associated with positive results of ICT tests. Patients with BUN >7 mmol/L, CURB-65 3-5, PCT > 2ng/mL were the top three groups with highest positive rate of ICT test (22.6%, 22.2% and 21.1% respectively). CONCLUSION: ICT test has a moderate sensitivity and high specificity in adults with CAP in China. Patients classified as sever pneumonia, or those with BUN > 7 mmol/L, or PCT > 2 ng/mL are more likely to have positive results.
Authors: Shawna Bellew; Carlos G Grijalva; Derek J Williams; Evan J Anderson; Richard G Wunderink; Yuwei Zhu; Grant W Waterer; Anna M Bramley; Seema Jain; Kathryn M Edwards; Wesley H Self Journal: Clin Infect Dis Date: 2019-05-30 Impact factor: 9.079
Authors: Carlos M Luna; Laura Pulido; Michael S Niederman; Alberto Casey; Diego Burgos; Sebastián D Leiva Agüero; Alejandra Grosso; Evangelina Membriani; Andrea C Entrocassi; Marcelo Rodríquez Fermepin; Carlos A Vay; Susana Garcia; Angela Famiglietti Journal: Pneumonia (Nathan) Date: 2018-09-25
Authors: Jesús Molina; Amelia González-Gamarra; Leovigildo Ginel; Mª Encarnación Peláez; Juan Luis Juez; Antonio Artuñedo; Gonzalo Aldana; Enriqueta Quesada; Joan Josep Cabré; Antonio Gómez; Manuel Linares; Maria Teresa Marín; Pilar Yolanda Sanchez; Leonor Núñez; Jaime Gonzálvez; Enrique Mascarós; Javier López; Agustina Cano; José Herrero; María Carmen Serra; Enrique Cimas; Marta Pedrol; Juan Vicente Alfaro; Federico Martinón-Torres; Isabel Cifuentes; Cristina Méndez; Daniel Ocaña Journal: Microorganisms Date: 2021-02-28