Literature DB >> 27437352

Assessment of White Spot Lesions and In-Vivo Evaluation of the Effect of CPP-ACP on White Spot Lesions in Permanent Molars of Children.

Deepti Munjal1, Shalini Garg2, Abhishek Dhindsa2, Gagandeep Kaur Sidhu3, Harsimran Singh Sethi1.   

Abstract

INTRODUCTION: As hindrance of remineralisation process occurs during orthodontic therapy resulting in decalcification of enamel because number of plaque retention sites increases due to banding and bonding of appliances to teeth. AIM: The present analytic study was undertaken to assess the occurrence of white spot lesions in permanent molars of children with and without orthodontic therapy and to evaluate the effect of Casein PhosphoPeptide-Amorphous Calcium Phosphate (CPP-ACP) on white spot lesions in post-orthodontic patients in a given period of time.
MATERIALS AND METHODS: The study comprised of examination of 679 first permanent molars which were examined to assess the occurrence of smooth surface white spot lesions in children of 8 to 16 years age group. Group I comprised subjects without any orthodontic treatment and Group II comprised of subjects who had undergone orthodontic therapy. The sample size was calculated using the epi-info6 computer package. Treatment group included 20 post-orthodontic patients examined with at least one white spot lesion within the enamel who received remineralizing cream (GC Tooth Mousse, Recaldent, GC Corporation.) i.e., CPP-ACP cream two times a day for 12 consecutive weeks. Computerized image analysis method was taken to evaluate white spot lesions. These frequency and percentages were compared with chi-square test. For comparison of numeric data, paired t-test was used.
RESULTS: Of the total 278 (49.6%) first permanent molars showed occurrence of smooth surface white spot lesions out of 560 in Group I and 107 (89.9%) first permanent molars showed presence of white spot lesions out of 119 debanded first permanent molars of children examined in Group II. CPP-ACP therapy group showed reduction in severity of codes which was found to be highly significant after 12 weeks and eight weeks on gingival-third, p-value (<0.001) and significant after eight weeks and four weeks on middle-third according to ICDAS II criteria and computerized image analysis.
CONCLUSION: CPP-ACP therapy minimum for 12 weeks is highly recommended as post-orthodontic treatment need in management of smooth surface white spot lesions on teeth undergoing fixed orthodontic therapy according to the present study.

Entities:  

Keywords:  Casein phosphopeptide-amorphous calcium phosphate; Decalcification; Incipient caries lesions; Orthodontics

Year:  2016        PMID: 27437352      PMCID: PMC4948528          DOI: 10.7860/JCDR/2016/19458.7896

Source DB:  PubMed          Journal:  J Clin Diagn Res        ISSN: 0973-709X


  22 in total

1.  Differentiation of developmental and post-orthodontic white lesions using image analysis.

Authors:  K Kanthathas; D R Willmot; P E Benson
Journal:  Eur J Orthod       Date:  2005-04       Impact factor: 3.075

2.  Efficacy of CPP-ACP and CPP-ACPF on enamel remineralization - an in vitro study using scanning electron microscope and DIAGNOdent.

Authors:  Jayanth Jayarajan; P Janardhanam; P Jayakumar
Journal:  Indian J Dent Res       Date:  2011 Jan-Feb

3.  Reproducibility and accuracy of three methods for assessment of demineralization depth of the occlusal surface: an in vitro examination.

Authors:  K R Ekstrand; D N Ricketts; E A Kidd
Journal:  Caries Res       Date:  1997       Impact factor: 4.056

4.  Regression of post-orthodontic lesions by a remineralizing cream.

Authors:  D L Bailey; G G Adams; C E Tsao; A Hyslop; K Escobar; D J Manton; E C Reynolds; M V Morgan
Journal:  J Dent Res       Date:  2009-11-03       Impact factor: 6.116

5.  White-spot lesions during multibracket appliance treatment: A challenge for clinical excellence.

Authors:  Mahmoud Enaia; Niko Bock; Sabine Ruf
Journal:  Am J Orthod Dentofacial Orthop       Date:  2011-07       Impact factor: 2.650

6.  Factors affecting demineralization during orthodontic treatment: a post-hoc analysis of RCT recruits.

Authors:  Emad F Al Maaitah; Adejumoke A Adeyemi; Susan M Higham; Neil Pender; Jayne E Harrison
Journal:  Am J Orthod Dentofacial Orthop       Date:  2011-02       Impact factor: 2.650

7.  Comparative evaluation of remineralization potential of casein phosphopeptide-amorphous calcium phosphate and casein phosphopeptide-amorphous calcium phosphate fluoride on artificial enamel white spot lesion: an in vitro light fluorescence study.

Authors:  R Mehta; B Nandlal; S Prashanth
Journal:  Indian J Dent Res       Date:  2013 Nov-Dec

8.  A randomized controlled trial of a 10 percent CPP-ACP cream to reduce mutans streptococci colonization.

Authors:  Margaret L Pukallus; Kathryn A Plonka; Trevor F Holcombe; Adrian G Barnett; Laurence J Walsh; W Kim Seow
Journal:  Pediatr Dent       Date:  2013       Impact factor: 1.874

9.  Effect of a dental cream containing amorphous cream phosphate complexes on white spot lesion regression assessed by laser fluorescence.

Authors:  Anita Andersson; Kerstin Sköld-Larsson; Anders Hallgren; Lars G Petersson; Svante Twetman
Journal:  Oral Health Prev Dent       Date:  2007       Impact factor: 1.256

10.  Comparative evaluation of remineralizing potential of three agents on artificially demineralized human enamel: An in vitro study.

Authors:  Namrata Patil; Shantanu Choudhari; Sadanand Kulkarni; Saurabh R Joshi
Journal:  J Conserv Dent       Date:  2013-03
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  8 in total

1.  Influence of CO2 Laser Irradiation and CPPACP Paste Application on Demineralized Enamel Microhardness.

Authors:  Zahra Khamverdi; Matin Kordestani; Narges Panahandeh; Fariba Naderi; Shahin Kasraei
Journal:  J Lasers Med Sci       Date:  2018-03-20

Review 2.  Application of Amorphous Calcium Phosphate Agents in the Prevention and Treatment of Enamel Demineralization.

Authors:  Jiarong Yan; Hongye Yang; Ting Luo; Fang Hua; Hong He
Journal:  Front Bioeng Biotechnol       Date:  2022-05-13

3.  Assessment of Streptococcus mutans biofilms on orthodontic adhesives over 7 days.

Authors:  Benjamin J Schneider; Rochelle D Hiers; G Frans Currier; Onur Kadioglu; Sarah E Johnston; Yan D Zhao; Fernando L Esteban Florez; Sharukh S Khajotia
Journal:  Am J Orthod Dentofacial Orthop       Date:  2021-06-03       Impact factor: 2.711

4.  A Retrospective Clinical Audit of Bracket Failure among Patients Undergoing Orthodontic Therapy.

Authors:  Dashrath Kafle; Rajeev Kumar Mishra; Md Riasat Hasan; Takashi Saito
Journal:  Int J Dent       Date:  2020-12-15

Review 5.  Changes in the Color and Brightness of White Spots Associated with Orthodontic Treatment 6 Months after the Application of Infiltrative Resins: Systematic Review and Meta-Analysis.

Authors:  Hugo Baptista-Sánchez; Laura Antonio-Zancajo; Alberto Albaladejo-Martínez; Pedro Colino Gallardo; Daniele Garcovich; Mario Alvarado-Lorenzo; Alfonso Alvarado-Lorenzo
Journal:  Int J Environ Res Public Health       Date:  2022-07-29       Impact factor: 4.614

6.  Impact of self-assembling peptides in remineralisation of artificial early enamel lesions adjacent to orthodontic brackets.

Authors:  Anahita Jablonski-Momeni; R Nothelfer; M Morawietz; A Kiesow; H Korbmacher-Steiner
Journal:  Sci Rep       Date:  2020-09-15       Impact factor: 4.379

7.  An In Vitro Study on the Effect of Amorphous Calcium Phosphate and Fluoride Solutions on Color Improvement of White Spot Lesions.

Authors:  Fahimeh Farzanegan; Hamideh Ameri; Ilnaz Miri Soleiman; Elham Khodaverdi; Abdolrasoul Rangrazi
Journal:  Dent J (Basel)       Date:  2018-06-22

8.  Effect of the caries-protective self-assembling peptide P11-4 on shear bond strength of metal brackets.

Authors:  Thomas Knaup; Heike Korbmacher-Steiner; Anahita Jablonski-Momeni
Journal:  J Orofac Orthop       Date:  2020-09-02       Impact factor: 1.938

  8 in total

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