| Literature DB >> 27437258 |
Priyanka Ramkrishna Rane1, Rakesh K Barot2, Devadatta Jayantilal Gohel3, Nupur Bhagat1.
Abstract
Chronic Myeloid Leukaemia (CML) causes retinopathy manifesting as venous dilation and tortuosity, perivascular sheathing, retinal haemorrhages, microaneurysms, cotton-wool spots and optic nerve infiltration. Retina is the most commonly involved intraocular structure in CML. However, retinal involvement is a rare form of presentation of CML and few cases have been reported. We report a case of CML presenting as unilateral sudden visual loss. Fundus showed multiple white centered retinal haemorrhages in both eyes with unilateral macular oedema. Blood work-up showed raised WBC count, high platelet count and low Haemoglobin. Cytological analysis of bone marrow biopsy confirmed Philadelphia chromosome. After a course of Imatinib, visual acuity improved and haemorrhages resolved with normalization of macular thickness. In our case, patient presented early, leading to early detection producing better visual prognosis. This highlights the importance of detailed hematological work up in patients with retinal involvement to rule out leukaemic retinopathy.Entities:
Keywords: Imatinib; Leukaemic infiltration; Macular oedema
Year: 2016 PMID: 27437258 PMCID: PMC4948434 DOI: 10.7860/JCDR/2016/18215.7822
Source DB: PubMed Journal: J Clin Diagn Res ISSN: 0973-709X