Literature DB >> 27437258

Chronic Myeloid Leukaemia Presenting as Bilateral Retinal Haemorrhages with Multiple Retinal Infiltrates.

Priyanka Ramkrishna Rane1, Rakesh K Barot2, Devadatta Jayantilal Gohel3, Nupur Bhagat1.   

Abstract

Chronic Myeloid Leukaemia (CML) causes retinopathy manifesting as venous dilation and tortuosity, perivascular sheathing, retinal haemorrhages, microaneurysms, cotton-wool spots and optic nerve infiltration. Retina is the most commonly involved intraocular structure in CML. However, retinal involvement is a rare form of presentation of CML and few cases have been reported. We report a case of CML presenting as unilateral sudden visual loss. Fundus showed multiple white centered retinal haemorrhages in both eyes with unilateral macular oedema. Blood work-up showed raised WBC count, high platelet count and low Haemoglobin. Cytological analysis of bone marrow biopsy confirmed Philadelphia chromosome. After a course of Imatinib, visual acuity improved and haemorrhages resolved with normalization of macular thickness. In our case, patient presented early, leading to early detection producing better visual prognosis. This highlights the importance of detailed hematological work up in patients with retinal involvement to rule out leukaemic retinopathy.

Entities:  

Keywords:  Imatinib; Leukaemic infiltration; Macular oedema

Year:  2016        PMID: 27437258      PMCID: PMC4948434          DOI: 10.7860/JCDR/2016/18215.7822

Source DB:  PubMed          Journal:  J Clin Diagn Res        ISSN: 0973-709X


  8 in total

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Journal:  Am J Ophthalmol       Date:  2003-03       Impact factor: 5.258

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Authors:  Neha Goel; Bhanu Pangtey; Meenakshi Thakar; Usha Kaul Raina; Basudeb Ghosh
Journal:  J AAPOS       Date:  2012-08       Impact factor: 1.220

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Journal:  Middle East Afr J Ophthalmol       Date:  2013 Oct-Dec
  8 in total
  2 in total

1.  Subjective intermittent colour vision loss as the initial presentation of chronic myeloid leukemia.

Authors:  Solin Saleh; Kaisra Esmail; Danah Albreiki
Journal:  Am J Ophthalmol Case Rep       Date:  2020-07-08

2.  Unilateral Macular Choroidal Neovascularization; a Rare Manifestation in Chronic Myelogenous Leukemia.

Authors:  Elias Khalili Pour; Fatemeh Bazvand; Mohammad Reza Mehrabi Bahar; Mahmood Davood Abadi; Hooshang Faghihi
Journal:  J Curr Ophthalmol       Date:  2020-03-23
  2 in total

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