Martins S Oderinde1, Natalie H Jones2, Antoine Juneau3, Mathieu Frenette3, Brian Aquila2, Sharon Tentarelli2, Daniel W Robbins2, Jeffrey W Johannes4. 1. Department of Chemistry (Oncology), AstraZeneca Pharmaceuticals LP, 35 Gatehouse Dr., Waltham, MA 0, 2451, USA. martins.oderinde@pfizer.com. 2. Department of Chemistry (Oncology), AstraZeneca Pharmaceuticals LP, 35 Gatehouse Dr., Waltham, MA 0, 2451, USA. 3. Département de Chimie, Université du Québec á Montréal, Case Postale 8888, Succursale Centre-Ville, Montréal, Quebec, H3C 3P8, Canada. 4. Department of Chemistry (Oncology), AstraZeneca Pharmaceuticals LP, 35 Gatehouse Dr., Waltham, MA 0, 2451, USA. jeffrey.johannes@astrazeneca.com.
Abstract
A visible-light-promoted iridium photoredox and nickel dual-catalyzed cross-coupling procedure for the formation C-N bonds has been developed. With this method, various aryl amines were chemoselectively cross-coupled with electronically and sterically diverse aryl iodides and bromides to forge the corresponding C-N bonds, which are of high interest to the pharmaceutical industries. Aryl iodides were found to be a more efficient electrophilic coupling partner. The coupling reactions were carried out at room temperature without the rigorous exclusion of molecular oxygen, thus making this newly developed Ir-photoredox/Ni dual-catalyzed procedure very mild and operationally simple.
A visible-light-promoted iridium photoredox and n class="Chemical">nickel dual-catalyzed cross-coupling procedure for the formation C-N bonds has been developed. With this method, various aryl amines were chemoselectively cross-coupled with electronically and sterically diverse aryl iodides and bromides to forge the corresponding C-N bonds, which are of high interest to the pharmaceutical industries. Aryl iodides were found to be a more efficient electrophilic coupling partner. The coupling reactions were carried out at room temperature without the rigorous exclusion of molecular oxygen, thus making this newly developed Ir-photoredox/Ni dual-catalyzed procedure very mild and operationally simple.
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