The Werner syndrome: a case study.

We present the neuropathological data of a 49-year-old patient with a history of Werner syndrome: The main features were arteriosclerosis of the small intracerebral arteries, cerebral atrophy and vascular myelopathy. In addition, there were marked lipofuscin deposition and corpora amylacea, but no neurofibrillary tangles or plaques. In comparison with pathological findings in other organ systems, the central nervous system shows mainly degenerative pathology in this disease.