Literature DB >> 27436033

Idiopathic choroidal neovascularisation in pregnancy: treatment options and a successful outcome.

Samantha Roshani De Silva1, Farhat Bibi1, Kuan Sim1, Mandeep Singh Bindra1.   

Abstract

Choroidal neovascularisation (CNV) is a major cause of visual loss and treatment options aim to halt progression and stabilise vision. We describe a 29-year-old woman who presented with blurred vision and distortion in her left eye while 26 weeks pregnant. She was diagnosed with idiopathic CNV and multiple treatment options were discussed. The patient did not want to undertake any risks from having an anti vascular endothelial growth factor agent during pregnancy. Therefore on discussion with the obstetric team, she elected to have early delivery at 32 weeks followed by a course of intravitreal bevacizumab. Subsequently there was resolution of symptoms and intraretinal and subretinal fluid. CNV is uncommonly seen in pregnancy and there remains no consensus on treatment. We describe the third reported case of idiopathic CNV in pregnancy. Careful patient counselling and close liaison between the ophthalmology and obstetric teams are necessary in this condition to obtain a safe outcome while maximising vision. 2016 BMJ Publishing Group Ltd.

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Year:  2016        PMID: 27436033      PMCID: PMC4964222          DOI: 10.1136/bcr-2016-215787

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  12 in total

1.  Maternal serum vascular endothelial growth factor during early pregnancy.

Authors:  P Evans; T Wheeler; F Anthony; C Osmond
Journal:  Clin Sci (Lond)       Date:  1997-06       Impact factor: 6.124

2.  Exposure to verteporfin and bevacizumab therapy for choroidal neovascularization secondary to punctate inner choroidopathy during pregnancy.

Authors:  E Rosen; A Rubowitz; J R Ferencz
Journal:  Eye (Lond)       Date:  2008-07-11       Impact factor: 3.775

3.  Early loss of pregnancy after intravitreal bevacizumab injection.

Authors:  Petros Petrou; Ilias Georgalas; Georgios Giavaras; Eleni Anastasiou; Zoi Ntana; Constantinos Petrou
Journal:  Acta Ophthalmol       Date:  2009-09-09       Impact factor: 3.761

4.  The natural history of idiopathic subfoveal choroidal neovascularization.

Authors:  A C Ho; L A Yannuzzi; K Pisicano; J DeRosa
Journal:  Ophthalmology       Date:  1995-05       Impact factor: 12.079

Review 5.  Pregnancy-associated retinal diseases and their management.

Authors:  Marie-Hélène Errera; Radha P Kohly; Lyndon da Cruz
Journal:  Surv Ophthalmol       Date:  2013 Mar-Apr       Impact factor: 6.048

6.  VEGF is major stimulator in model of choroidal neovascularization.

Authors:  N Kwak; N Okamoto; J M Wood; P A Campochiaro
Journal:  Invest Ophthalmol Vis Sci       Date:  2000-09       Impact factor: 4.799

7.  Intravitreal bevacizumab injection in unrecognised early pregnancy.

Authors:  L Sullivan; S P Kelly; A Glenn; C P R Williams; M McKibbin
Journal:  Eye (Lond)       Date:  2014-01-17       Impact factor: 3.775

8.  Punctate inner choroidopathy-associated choroidal neovascular membranes during pregnancy.

Authors:  D A Sim; H G Sheth; A Kaines; A Tufail
Journal:  Eye (Lond)       Date:  2008-03-28       Impact factor: 3.775

9.  The prognosis of idiopathic choroidal neovascularization in persons younger than 50 years of age.

Authors:  B Lindblom; T Andersson
Journal:  Ophthalmology       Date:  1998-10       Impact factor: 12.079

10.  Peripapillary Neovascular Membrane in a Young Pregnant Woman and Prompt Response to Ranibizumab Injections following Uneventful Delivery.

Authors:  Konstantinos Anastasilakis; Chrysanthos Symeonidis; Konstantinos Kaprinis; Asimina Mataftsi; Argyrios Tzamalis; Stavros A Dimitrakos
Journal:  Case Rep Ophthalmol       Date:  2011-04-22
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