Sweta Kumari1, Vikram Datta2, Harmeet Rehan3. 1. Department of Pediatrics, Lady Hardinge Medical College, New Delhi 110001, India. 2. Department of Neonatology, Lady Hardinge Medical College, New Delhi 110001, India drvikramdatta@gmail.com. 3. Department of Pharmacology, Lady Hardinge Medical College, New Delhi 110001, India.
Abstract
AIM: To study the analgesic effect of oral 25% glucose as compared with oral 24% sucrose during heel lance in preterm neonates. METHODS:Stable preterm neonates within first 48 hours of life were randomized to receive either 24% sucrose or 25% glucose before heel lance. Primary outcome assessed was painful response by the Premature Infant Pain Profile (PIPP) score at 30 seconds after heel lance, and the secondary outcome was immediate adverse events associated with the administration of two solutions and duration of crying immediately following the procedure. RESULTS:A total of 94 neonates were randomly assigned into 24% sucrose and 25% glucose group. The baseline characteristics between the two groups were comparable. No significant difference was observed between the two study groups with respect to PIPP scores, duration of crying and rate of adverse events. CONCLUSIONS: When assessed by PIPP score, 25% glucose and 24% sucrose provided comparable analgesia during heel lance in preterm neonates.
RCT Entities:
AIM: To study the analgesic effect of oral 25% glucose as compared with oral 24% sucrose during heel lance in preterm neonates. METHODS: Stable preterm neonates within first 48 hours of life were randomized to receive either 24% sucrose or 25% glucose before heel lance. Primary outcome assessed was painful response by the Premature InfantPain Profile (PIPP) score at 30 seconds after heel lance, and the secondary outcome was immediate adverse events associated with the administration of two solutions and duration of crying immediately following the procedure. RESULTS: A total of 94 neonates were randomly assigned into 24% sucrose and 25% glucose group. The baseline characteristics between the two groups were comparable. No significant difference was observed between the two study groups with respect to PIPP scores, duration of crying and rate of adverse events. CONCLUSIONS: When assessed by PIPP score, 25% glucose and 24% sucrose provided comparable analgesia during heel lance in preterm neonates.
Authors: Débora Joyce Duarte Oliveira; Kleyton Santos Medeiros; Ayane Cristine Alves Sarmento; Francisca Jennifer Duarte Oliveira; Ana Paula Ferreira Costa; Nilba Lima Souza; Ana Katherine Gonçalves; Maria de Lourdes Costa Silva Journal: BMJ Open Date: 2021-12-09 Impact factor: 2.692