Literature DB >> 27435670

NHX-5, an Endosomal Na+/H+ Exchanger, Is Associated with Metformin Action.

Jeongho Kim1, Hye-Yeon Lee1, Jheesoo Ahn2, Moonjung Hyun2, Inhwan Lee2, Kyung-Jin Min1, Young-Jai You3.   

Abstract

Diabetes is one of the most impactful diseases worldwide. The most commonly prescribed anti-diabetic drug is metformin. In this study, we identified an endosomal Na(+)/H(+) exchanger (NHE) as a new potential target of metformin from an unbiased screen in Caenorhabditis elegans The same NHE homolog also exists in flies, where it too mediates the effects of metformin. Our results suggest that endosomal NHEs could be a metformin target and provide an insight into a novel mechanism of action of metformin on regulating the endocytic cycle.
© 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

Entities:  

Keywords:  Caenorhabditis elegans (C. elegans); Type 2 diabetes; autophagy; drug action; endosome; metformin; sodium-proton exchange

Mesh：

Substances：

Year:  2016        PMID： 27435670      PMCID： PMC5000102          DOI： 10.1074/jbc.C116.744037

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  47 in total

1.  Rapid gene mapping in Caenorhabditis elegans using a high density polymorphism map.

Authors:  S R Wicks; R T Yeh; W R Gish; R H Waterston; R H Plasterk
Journal:  Nat Genet       Date:  2001-06       Impact factor: 38.330

2.  The NHX family of Na+-H+ exchangers in Caenorhabditis elegans.

Authors:  Keith Nehrke; James E Melvin
Journal:  J Biol Chem       Date:  2002-05-20       Impact factor: 5.157

3.  Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain.

Authors:  M R Owen; E Doran; A P Halestrap
Journal:  Biochem J       Date:  2000-06-15       Impact factor: 3.857

Review 4.  Organellar Na+/H+ exchangers: novel players in organelle pH regulation and their emerging functions.

Authors:  Ryuichi Ohgaki; Sven C D van IJzendoorn; Masafumi Matsushita; Dick Hoekstra; Hiroshi Kanazawa
Journal:  Biochemistry       Date:  2010-12-30       Impact factor: 3.162

5.  Molecular cloning, primary structure, and expression of the human growth factor-activatable Na+/H+ antiporter.

Authors:  C Sardet; A Franchi; J Pouysségur
Journal:  Cell       Date:  1989-01-27       Impact factor: 41.582

Review 6.  Autophagy dysfunction and its link to Alzheimer's disease and type II diabetes mellitus.

Authors:  Cornelia M Wilson; Amandine Magnaudeix; Catherine Yardin; Faraj Terro
Journal:  CNS Neurol Disord Drug Targets       Date:  2014-03       Impact factor: 4.388

Review 7.  Metformin: from mechanisms of action to therapies.

Authors:  Marc Foretz; Bruno Guigas; Luc Bertrand; Michael Pollak; Benoit Viollet
Journal:  Cell Metab       Date:  2014-10-30       Impact factor: 27.287

8.  Starvation activates MAP kinase through the muscarinic acetylcholine pathway in Caenorhabditis elegans pharynx.

Authors:  Young-jai You; Jeongho Kim; Melanie Cobb; Leon Avery
Journal:  Cell Metab       Date:  2006-04       Impact factor: 27.287

9.  Improvement of cardiac functions by chronic metformin treatment is associated with enhanced cardiac autophagy in diabetic OVE26 mice.

Authors:  Zhonglin Xie; Kai Lau; Bonnie Eby; Pedro Lozano; Chaoyong He; Becky Pennington; Hongliang Li; Shradha Rathi; Yunzhou Dong; Rong Tian; David Kem; Ming-Hui Zou
Journal:  Diabetes       Date:  2011-05-11       Impact factor: 9.461

10.  Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4.4 million participants.

Authors: 
Journal:  Lancet       Date:  2016-04-06       Impact factor: 79.321
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  6 in total

1.  AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System.

Authors:  Jingyue Jia; Bhawana Bissa; Lukas Brecht; Lee Allers; Seong Won Choi; Yuexi Gu; Mark Zbinden; Mark R Burge; Graham Timmins; Kenneth Hallows; Christian Behrends; Vojo Deretic
Journal:  Mol Cell       Date:  2020-01-28       Impact factor: 17.970

2.  Histone deacetylase-mediated regulation of endolysosomal pH.

Authors:  Hari Prasad; Rajini Rao
Journal:  J Biol Chem       Date:  2018-03-22       Impact factor: 5.157

Review 3.  The Effectiveness of Antidiabetic Drugs in Treating Dementia: A Peek into Pharmacological and Pharmacokinetic Properties.

Authors:  Jiro Ogura; Hiroaki Yamaguchi
Journal:  Int J Mol Sci       Date:  2022-06-11       Impact factor: 6.208

4.  Activating AMPK to Restore Tight Junction Assembly in Intestinal Epithelium and to Attenuate Experimental Colitis by Metformin.

Authors:  Lu Chen; Jie Wang; Qian You; Shuai He; Qianqian Meng; Jian Gao; Xudong Wu; Yan Shen; Yang Sun; Xuefeng Wu; Qiang Xu
Journal:  Front Pharmacol       Date:  2018-07-16       Impact factor: 5.810

Review 5.  Skeletal Muscle-Released Extracellular Vesicles: State of the Art.

Authors:  Sophie Rome; Alexis Forterre; Maria Luisa Mizgier; Karim Bouzakri
Journal:  Front Physiol       Date:  2019-08-09       Impact factor: 4.566

Review 6.  Mechanisms of action of metformin in type 2 diabetes: Effects on mitochondria and leukocyte-endothelium interactions.

Authors:  Nadezda Apostolova; Francesca Iannantuoni; Aleksandra Gruevska; Jordi Muntane; Milagros Rocha; Victor M Victor
Journal:  Redox Biol       Date:  2020-05-25       Impact factor: 11.799
  6 in total

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