| Literature DB >> 2743478 |
M Uchida, M Komatsu, S Morita, T Kanbe, K Nakagawa.
Abstract
A series of tetrazole alkanamides was synthesized and tested for antiulcer activity against acetic acid-induced gastric ulcer in rats. These compounds were prepared by the reaction of tetrazole alkanoic acids and various amines by the mixed anhydride method or acid chloride method. Among them, 3-[(1-ethyl-5-tetrazolyl)methylthio]propionamide (IIn) was found to have the most potent activity. The structure-activity relationships are discussed.Entities:
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Year: 1989 PMID： 2743478 DOI： 10.1248/cpb.37.322
Source DB: PubMed Journal: Chem Pharm Bull (Tokyo) ISSN： 0009-2363 Impact factor: 1.645