Literature DB >> 2743394

Cellular origin and distribution of transforming growth factor-beta in the normal rat myocardium.

M Eghbali1.   

Abstract

Transforming growth factor-beta (TGF-beta) is a biologically active polypeptide present in normal tissues as well as transformed cells. Two structurally related forms of this peptide are TGF-beta 1 and TGF-beta 2. Using freshly isolated cardiomyocytes and non-myocyte heart cells, and a [32P]- labelled cDNA probe to human TGF-beta 1, we demonstrated that mRNA for TGF-beta 1 could be detected only in the nonmyocyte fraction of heart cells. In the present study, the distribution of TGF-beta 1 in the heart was determined by immunofluorescence staining by use of a polyclonal antibody to porcine TGF-beta 1 in cryostat sections of rat heart. Immunofluorescence staining was intense around the blood vessels and radially diffuse in the surrounding myocardium.

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Year:  1989        PMID： 2743394     DOI： 10.1007/bf00225603

Source DB:  PubMed          Journal:  Cell Tissue Res        ISSN： 0302-766X            Impact factor:   5.249


  26 in total

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5.  Expression of type I and III collagen genes during differentiation of embryonic chicken myoblasts in culture.

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Journal:  Mol Cell Biol       Date:  1984-08       Impact factor: 4.272

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9.  Human actin genes are single copy for alpha-skeletal and alpha-cardiac actin but multicopy for beta- and gamma-cytoskeletal genes: 3' untranslated regions are isotype specific but are conserved in evolution.

Authors:  P Ponte; P Gunning; H Blau; L Kedes
Journal:  Mol Cell Biol       Date:  1983-10       Impact factor: 4.272

10.  Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization.

Authors:  R K Assoian; A Komoriya; C A Meyers; D M Miller; M B Sporn
Journal:  J Biol Chem       Date:  1983-06-10       Impact factor: 5.157
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  15 in total

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Authors:  M Griffin; H W Lee; L Zhao; M Eghbali-Webb
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Review 5.  Intramyocardial fibroblast myocyte communication.

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Review 6.  Role of extracellular matrix proteins in heart function.

Authors:  V Pelouch; I M Dixon; L Golfman; R E Beamish; N S Dhalla
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7.  Regulation of mRNA transcripts and DNA synthesis in the rat heart following intravenous injection of transforming growth factor beta 1.

Authors:  A Sigel; J A Douglas; M Eghbali-Webb
Journal:  Mol Cell Biochem       Date:  1994-12-21       Impact factor: 3.396

8.  A growth factor for cardiac myocytes is produced by cardiac nonmyocytes.

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Journal:  Cell Regul       Date:  1991-12

Review 9.  Myocyte-fibroblast communication in cardiac fibrosis and arrhythmias: Mechanisms and model systems.

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10.  Hypertrophic stimuli induce transforming growth factor-beta 1 expression in rat ventricular myocytes.

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Journal:  J Clin Invest       Date:  1994-10       Impact factor: 14.808
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