Sir,With reference to the interesting case report by Arora et al.,[1] there are three prevailing health threats in India. Giardiasis is a significant cause of diarrheal disease, and it is associated with a significant morbidity in children and adults. The available data pointed out to a substantial prevalence rate of giardia infection in patients with diarrhea in India (0.4–70%).[2] Tuberculosis (TB) is another public health problem of great significance in India. The recently published data indicated an alarming increase in the prevalence of multidrug-resistant TB (P < 0.001) by 12% (4.7% in 2000–19.8% in 2012).[3] Human immunodeficiency virus (HIV) infection is still imposing a great health burden in India. The recently published data showed that the estimated adult HIV prevalence retained a declining trend in India, following its peak in 2002 at a level of 0.41% (within bounds 0.35–0.47%). By 2010 and 2011, it leveled at estimates of 0.28% (0.24–0.34%) and 0.27% (0.22–0.33%), respectively.[4] It is obvious that there are numerous ophthalmic manifestations in patients with HIV infection in the era of highly active antiretroviral therapy, where 7% of the patients in India were found to present with ophthalmological features as the initial manifestation of HIV infection. Moreover, most (70%) of the ophthalmic manifestations of HIV infection were presented when CD4 count was <200 cells/μL.[5] I presume that the constellation of peripheral ulcerative keratitis (PUK), chronic malabsorption syndrome due to giardiasis, and miliary TB in the case in question should alert the authors to the underlying immune deficiency status, particularly HIV infection. Hence, the diagnostic algorithm of CD4 count and viral overload measurements was solicited to be contemplated by the authors. If that diagnostic algorithm was done and it disclosed a concomitant HIV infection, the case in question could be regarded as a novel case report, as concurrent occurrence of the three infections in a patient with PUK has never been reported in the literature.