Itahisa Marcelino Rodríguez1,2, José Oliva García3, José Juan Alemán Sánchez1,2,4, Delia Almeida González2,5, Santiago Domínguez Coello2,4, Buenaventura Brito Díaz1,4, Fadoua Gannar6, María Del Cristo Rodríguez Pérez1,4, Roberto Elosua2,7, Antonio Cabrera de León8,9. 1. Research Unit, University Hospital Nuestra Señora de la Candelaria, Carretera de El Rosario 145, 38010, Santa Cruz de Tenerife, Canary Islands, Spain. 2. Cardiovascular Research Network of the Carlos III Institute of Health, Santa Cruz de Tenerife, Spain. 3. Research Unit, University Hospital Nuestra Señora de la Candelaria, Santa Cruz de Tenerife, Spain. 4. Primary Care Authority, Santa Cruz de Tenerife, Spain. 5. Immunology Unit, University Hospital Nuestra Señora de la Candelaria, Santa Cruz de Tenerife, Spain. 6. Faculty of Sciences of Bizerte, Carthage University, Tunis, Tunisia. 7. Cardiovascular Epidemiology and Genetics, IMIM, Barcelona, Spain. 8. Research Unit, University Hospital Nuestra Señora de la Candelaria, Carretera de El Rosario 145, 38010, Santa Cruz de Tenerife, Canary Islands, Spain. acableo@gobiernodecanarias.org. 9. Área de medicina preventiva y salud pública, Universidad de La Laguna, La Laguna, Spain. acableo@gobiernodecanarias.org.
Abstract
AIMS: To analyze the serum lipid and inflammatory biomarker profile in the early insulin resistance (e-IR). METHODS: Cross-sectional study of 5943 adults without diabetes, stratified into no IR group (C-peptide <third tertile and glucose <100 mg/dL), e-IR group (C-peptide ≥third tertile and glucose <100 mg/dL) and advanced IR group (glucose ≥100 mg/dL). RESULTS: E-IR showed significant differences with no IR in the serum concentration of triglycerides (P < 0.001), HDL cholesterol (P < 0.001), LDL cholesterol (P < 0.001), sCD40L (P < 0.001), C-reactive protein (P < 0.004), leptin (P < 0.001) and adiponectin (P < 0.001). Adjusting for age, gender and abdominal obesity, corroborated the association of e-IR with highest quintile of triglycerides (OR 3.88 [3.07-4.89]), HDL cholesterol (OR 0.35 [0.28-0.44]), sCD40L (OR 0.47 [0.24-0.94]), C-reactive protein (OR 2.31 [1.29-4.12]), adiponectin (OR 0.11 [0.04-0.32]), PAI-1 (OR 3.29 [1.29-8.40]) and resistin (OR 1.25 [1.01-1.54]); the same biomarkers were associated with advanced IR although resistin was a protective factor (OR 0.73 [0.58-0.93]). CONCLUSIONS: Euglycemic patients with e-IR present an unfavorable serum lipid and inflammatory biomarker profile. Measuring C-peptide in euglycemic patients with elevated triglycerides identifies e-IR.
AIMS: To analyze the serum lipid and inflammatory biomarker profile in the early insulin resistance (e-IR). METHODS: Cross-sectional study of 5943 adults without diabetes, stratified into no IR group (C-peptide <third tertile and glucose <100 mg/dL), e-IR group (C-peptide ≥third tertile and glucose <100 mg/dL) and advanced IR group (glucose ≥100 mg/dL). RESULTS: E-IR showed significant differences with no IR in the serum concentration of triglycerides (P < 0.001), HDL cholesterol (P < 0.001), LDL cholesterol (P < 0.001), sCD40L (P < 0.001), C-reactive protein (P < 0.004), leptin (P < 0.001) and adiponectin (P < 0.001). Adjusting for age, gender and abdominal obesity, corroborated the association of e-IR with highest quintile of triglycerides (OR 3.88 [3.07-4.89]), HDL cholesterol (OR 0.35 [0.28-0.44]), sCD40L (OR 0.47 [0.24-0.94]), C-reactive protein (OR 2.31 [1.29-4.12]), adiponectin (OR 0.11 [0.04-0.32]), PAI-1 (OR 3.29 [1.29-8.40]) and resistin (OR 1.25 [1.01-1.54]); the same biomarkers were associated with advanced IR although resistin was a protective factor (OR 0.73 [0.58-0.93]). CONCLUSIONS: Euglycemic patients with e-IR present an unfavorable serum lipid and inflammatory biomarker profile. Measuring C-peptide in euglycemic patients with elevated triglycerides identifies e-IR.
Authors: Sang Woo Kim; Jung-Won Choi; Jong Won Yun; In-Sung Chung; Ho Chan Cho; Seung-Eun Song; Seung-Soon Im; Dae-Kyu Song Journal: PLoS One Date: 2019-09-10 Impact factor: 3.240