In Sook Kang1, Wonkyung Lee2, Byoung Wook Choi3, Donghoon Choi2, Myeong-Ki Hong1, Yangsoo Jang1, Young-Guk Ko4. 1. Division of Cardiology, Cardiovascular Research Institute, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea; Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, Republic of Korea. 2. Division of Cardiology, Cardiovascular Research Institute, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea. 3. Department of Radiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea. 4. Division of Cardiology, Cardiovascular Research Institute, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address: ygko@yuhs.ac.
Abstract
OBJECTIVE: Tibial artery calcification (TAC) is associated with increased risk of amputation and mortality in peripheral artery disease. We sought to investigate whether the severity of TAC based on semiquantitative analysis of computed tomography angiography (CTA) can predict outcomes of endovascular therapy in patients with critical limb ischemia. METHODS: We reviewed medical records of 124 patients who underwent lower extremity CTA before intervention. Based on CTA, TAC severity was categorized into three groups: minimal calcification (MC; n = 43), intermediate calcification (IC; n = 36), or extensive calcification (EC; n = 45). Immediate and late outcomes of infrapopliteal interventions were compared, and predictors of the outcomes were investigated. RESULTS: The categorized severity of target TAC correlated with the log-transformed TAC score (r = 0.873; P < .001). The EC group was younger and had more diabetes and chronic kidney disease compared with the MC or IC group (all P < .001). The technical success was lower in the EC group (71.1%) than in the MC (95.3%) or IC (91.7%) group (P = .001). The survival free of unplanned amputations at 2 years was significantly lower in the EC group (58.9%) than in the MC (79.0%) or IC (95.3%) group (P < .001). Extensive TAC was an independent predictor of technical success (hazard ratio, 0.02; 95% confidence interval, 0.00-0.45; P = .014) and unplanned amputation (hazard ratio, 9.90; 95% confidence interval, 2.05-47.75; P = .004). CONCLUSIONS: The categorized severity of TAC by semiquantitative analysis of CTA correlated with TAC score, and extensive TAC was associated with a lower technical success rate of angioplasty and an increased incidence of unplanned amputation.
OBJECTIVE:Tibial artery calcification (TAC) is associated with increased risk of amputation and mortality in peripheral artery disease. We sought to investigate whether the severity of TAC based on semiquantitative analysis of computed tomography angiography (CTA) can predict outcomes of endovascular therapy in patients with critical limb ischemia. METHODS: We reviewed medical records of 124 patients who underwent lower extremity CTA before intervention. Based on CTA, TAC severity was categorized into three groups: minimal calcification (MC; n = 43), intermediate calcification (IC; n = 36), or extensive calcification (EC; n = 45). Immediate and late outcomes of infrapopliteal interventions were compared, and predictors of the outcomes were investigated. RESULTS: The categorized severity of target TAC correlated with the log-transformed TAC score (r = 0.873; P < .001). The EC group was younger and had more diabetes and chronic kidney disease compared with the MC or IC group (all P < .001). The technical success was lower in the EC group (71.1%) than in the MC (95.3%) or IC (91.7%) group (P = .001). The survival free of unplanned amputations at 2 years was significantly lower in the EC group (58.9%) than in the MC (79.0%) or IC (95.3%) group (P < .001). Extensive TAC was an independent predictor of technical success (hazard ratio, 0.02; 95% confidence interval, 0.00-0.45; P = .014) and unplanned amputation (hazard ratio, 9.90; 95% confidence interval, 2.05-47.75; P = .004). CONCLUSIONS: The categorized severity of TAC by semiquantitative analysis of CTA correlated with TAC score, and extensive TAC was associated with a lower technical success rate of angioplasty and an increased incidence of unplanned amputation.
Authors: Bright Benfor; Kavya Sinha; Christof Karmonik; Alan B Lumsden; Trisha L Roy Journal: J Cardiovasc Transl Res Date: 2022-09-14 Impact factor: 3.216
Authors: Nathan K Itoga; Vy T Ho; Kenneth Tran; Venita Chandra; Ronald L Dalman; Edmund J Harris; Jason T Lee; Matthew W Mell Journal: Vasc Endovascular Surg Date: 2019-11-20 Impact factor: 1.089