Joon-Hyop Lee1, Young Jun Chai2,3, Tae-Hyung Kim4, June Young Choi1, Kyu Eun Lee5,6, Hyun-Young Kim7, Yoo-Seok Yoon1, Hyeon Hoe Kim8. 1. Department of Surgery, Seoul National University Bundang Hospital, 300 Gumi-dong Bundang-gu, Seongnam-si, Gyeonggi-do, Korea. 2. Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea. 3. Department of Surgery, Seoul National University Boramae Medical Center, 20 Boramae-ro 5-gil, Dongjak-gu, Seoul, Korea. 4. Department of Radiology, Seoul National University Hospital and College of Medicine, 101 Daeak-ro, Jongno-gu, Seoul, Korea. 5. Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea. kyueunlee@snu.ac.kr. 6. Department of Surgery, Seoul National University Hospital and College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, Korea. kyueunlee@snu.ac.kr. 7. Department of Pediatric Surgery, Seoul National University Children's Hospital, 101 Daehak-ro, Jongno-gu, Seoul, Korea. 8. Department of Urology, Seoul National University Hospital and College of Medicine, 101 Daeak-ro, Jongno-gu, Seoul, Korea.
Abstract
BACKGROUND: Ganglioneuromas are benign tumors that rarely develop from adrenal glands. In this study, we present our clinical experience of patients with adrenal ganglioneuroma (AGN). METHODS: Demographic, diagnostic, surgical, and pathologic findings of patients who were adrenalectomized as a result of AGN were retrospectively reviewed from the database of a tertiary referral hospital. RESULTS: Among 1784 patients who underwent an adrenalectomy between 2002 and 2015, 35 (1.9 %; 14 males, 21 females) were diagnosed with AGN. Mean age was 33.4 ± 18.7 years (0-84). Twenty-nine (82.9 %) were asymptomatic, four (11.4 %) complained of abdominal discomfort, and two (5.7 %) had abdominal distension. Preoperative computed tomography (CT) reported AGN in 22 (62.9 %) cases. Precontrast Hounsfield units, increased postcontrast phase attenuation, and well-defined borders were characteristic CT features of AGN. Mean tumor size was 6.3 ± 3.3 cm (range, 1.5-16.0). No recurrence occurred during a median follow-up period of 19 months (range, 1-120). CONCLUSION: AGN was asymptomatic in most cases and diagnosis may be challenging. Adrenalectomy is a safe treatment modality for AGN and ensures favorable outcomes when diagnosed.
BACKGROUND: Ganglioneuromas are benign tumors that rarely develop from adrenal glands. In this study, we present our clinical experience of patients with adrenal ganglioneuroma (AGN). METHODS: Demographic, diagnostic, surgical, and pathologic findings of patients who were adrenalectomized as a result of AGN were retrospectively reviewed from the database of a tertiary referral hospital. RESULTS: Among 1784 patients who underwent an adrenalectomy between 2002 and 2015, 35 (1.9 %; 14 males, 21 females) were diagnosed with AGN. Mean age was 33.4 ± 18.7 years (0-84). Twenty-nine (82.9 %) were asymptomatic, four (11.4 %) complained of abdominal discomfort, and two (5.7 %) had abdominal distension. Preoperative computed tomography (CT) reported AGN in 22 (62.9 %) cases. Precontrast Hounsfield units, increased postcontrast phase attenuation, and well-defined borders were characteristic CT features of AGN. Mean tumor size was 6.3 ± 3.3 cm (range, 1.5-16.0). No recurrence occurred during a median follow-up period of 19 months (range, 1-120). CONCLUSION: AGN was asymptomatic in most cases and diagnosis may be challenging. Adrenalectomy is a safe treatment modality for AGN and ensures favorable outcomes when diagnosed.
Authors: Z Bencsik; I Szabolcs; M Góth; O Dohán; L Kovács; I Kaszás; G Gonda; I Szilvási; G Szilágyi Journal: Orv Hetil Date: 1999-03-14 Impact factor: 0.540
Authors: Kelley N Dages; Jacob D Kohlenberg; William F Young; Mohammad Hassan Murad; Larry Prokop; Michael Rivera; Benzon Dy; Trenton Foster; Melanie Lyden; Travis McKenzie; Geoffrey Thompson; Irina Bancos Journal: Clin Endocrinol (Oxf) Date: 2021-03-22 Impact factor: 3.523