| Literature DB >> 27430892 |
Munetaka Nakamura1, Jun Nishikawa2, Mari Saito1, Kouhei Sakai3, Sho Sasaki1, Shinichi Hashimoto1, Takeshi Okamoto1, Yutaka Suehiro3, Takahiro Yamasaki3, Isao Sakaida1.
Abstract
The present study investigated the effect of a DNA demethylating agent, decitabine, against Epstein-Barr virus-associated gastric cancer (EBVaGC). Decitabine inhibited cell growth and induced G2/M arrest and apoptosis in EBVaGC cell lines. The expression of E-cadherin was up-regulated and cell motility was significantly inhibited in the cells treated with decitabine. The promoter regions of p73 and RUNX3 were demethylated, and their expression was up-regulated by decitabine. They enhanced the transcription of p21, which induced G2/M arrest and apoptosis through down-regulation of c-Myc. Decitabine also induced the expression of BZLF1 in SNU719. Induction of EBV lytic infection was an alternative way to cause apoptosis of the host cells. This study is the first report to reveal the effectiveness of a demethylating agent in inhibiting tumor cell proliferation and up-regulation of E-cadherin in EBVaGC. J. Med. Virol. 89:508-517, 2017.Entities:
Keywords: Epstein-Barr virus; apoptosis/cell death; gastrointestinal analysis; tumor suppressor genes
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Year: 2016 PMID： 27430892 DOI： 10.1002/jmv.24634
Source DB: PubMed Journal: J Med Virol ISSN： 0146-6615 Impact factor: 2.327