Literature DB >> 27429994

A Brain in a Dish.

Shikha Jain Goodwin1.   

Abstract

Ohio State University researchers have made a leap forward in disease research by creating an eraser sized human "brain" in a petri dish1. Although lacking a circulatory system their brain model includes spinal cord, cortex, midbrain, brain stem, and even the beginnings of an eye- aiding in the effectiveness of research on complex neurological disease. To create their new brain model, the researchers converted adult skin cells into pluripotent stem cells, which afforded the opportunity to build the multiple nervous cell types required for such a complex system. Having this tissue model will assist researchers in developing new disease models, and thus, facilitate the development of novel clinical interventions.

Entities:  

Keywords:  brain; brain stem; cortex; midbrain; spinal cord

Year:  2015        PMID: 27429994      PMCID: PMC4946643     

Source DB:  PubMed          Journal:  Postdoc J        ISSN: 2328-9791


  7 in total

1.  An intrinsic mechanism of corticogenesis from embryonic stem cells.

Authors:  Nicolas Gaspard; Tristan Bouschet; Raphael Hourez; Jordane Dimidschstein; Gilles Naeije; Jelle van den Ameele; Ira Espuny-Camacho; Adèle Herpoel; Lara Passante; Serge N Schiffmann; Afsaneh Gaillard; Pierre Vanderhaeghen
Journal:  Nature       Date:  2008-08-17       Impact factor: 49.962

2.  Self-organized formation of polarized cortical tissues from ESCs and its active manipulation by extrinsic signals.

Authors:  Mototsugu Eiraku; Kiichi Watanabe; Mami Matsuo-Takasaki; Masako Kawada; Shigenobu Yonemura; Michiru Matsumura; Takafumi Wataya; Ayaka Nishiyama; Keiko Muguruma; Yoshiki Sasai
Journal:  Cell Stem Cell       Date:  2008-11-06       Impact factor: 24.633

3.  Self-organization of polarized cerebellar tissue in 3D culture of human pluripotent stem cells.

Authors:  Keiko Muguruma; Ayaka Nishiyama; Hideshi Kawakami; Kouichi Hashimoto; Yoshiki Sasai
Journal:  Cell Rep       Date:  2015-01-29       Impact factor: 9.423

4.  Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture.

Authors:  Anca M Paşca; Steven A Sloan; Laura E Clarke; Yuan Tian; Christopher D Makinson; Nina Huber; Chul Hoon Kim; Jin-Young Park; Nancy A O'Rourke; Khoa D Nguyen; Stephen J Smith; John R Huguenard; Daniel H Geschwind; Ben A Barres; Sergiu P Paşca
Journal:  Nat Methods       Date:  2015-05-25       Impact factor: 28.547

5.  Altered TFEB-mediated lysosomal biogenesis in Gaucher disease iPSC-derived neuronal cells.

Authors:  Ola Awad; Chinmoy Sarkar; Leelamma M Panicker; Diana Miller; Xianmin Zeng; Judi A Sgambato; Marta M Lipinski; Ricardo A Feldman
Journal:  Hum Mol Genet       Date:  2015-07-28       Impact factor: 6.150

Review 6.  Cortical neurogenesis from pluripotent stem cells: complexity emerging from simplicity.

Authors:  Stewart Anderson; Pierre Vanderhaeghen
Journal:  Curr Opin Neurobiol       Date:  2014-04-18       Impact factor: 6.627

7.  Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome.

Authors:  Sergiu P Paşca; Thomas Portmann; Irina Voineagu; Masayuki Yazawa; Aleksandr Shcheglovitov; Anca M Paşca; Branden Cord; Theo D Palmer; Sachiko Chikahisa; Seiji Nishino; Jonathan A Bernstein; Joachim Hallmayer; Daniel H Geschwind; Ricardo E Dolmetsch
Journal:  Nat Med       Date:  2011-11-27       Impact factor: 53.440

  7 in total

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