Literature DB >> 27429516

Acute Myeloid Leukemia in Children: Experience from Tertiary Cancer Centre in India.

Venkatraman Radhakrishnan1, Cherian Thampy1, Prasanth Ganesan1, Rejiv Rajendranath1, Trivadi S Ganesan1, K R Rajalekshmy2, Tenali Gnana Sagar1.   

Abstract

There is paucity of data in pediatric Acute Myeloid Leukemia (AML) from developing countries. We analyzed the outcomes of 65 consecutive patients with pediatric AML treated at our centre from January-2008 to May-2013. The median event free survival (EFS) and overall survival (OS) were 12.6 and 14.6 months respectively. Patients with good-risk cytogenetics had a better EFS (p = 0.004) and OS (p = 0.01). Overall, these results are not comparable to that observed in other centres globally and leaves scope for further improvement. This includes implementing allogeneic bone marrow transplantation as a treatment for all children with high-risk AML.

Entities:  

Keywords:  Acute Myeloid Leukemia; Chemotherapy; Survival

Year:  2015        PMID： 27429516      PMCID： PMC4930761          DOI： 10.1007/s12288-015-0591-5

Source DB:  PubMed          Journal:  Indian J Hematol Blood Transfus        ISSN： 0971-4502            Impact factor:   0.900


  10 in total

Review 1.  Mitochondrial D-loop variations in paediatric acute myeloid leukaemia: a potential prognostic marker.

Authors:  Surender K Sharawat; Radhika Bakhshi; Sreenivas Vishnubhatla; Sameer Bakhshi
Journal:  Br J Haematol       Date:  2010-03-08       Impact factor: 6.998

Review 2.  Cytogenetics of pediatric acute myeloid leukemia.

Authors:  Kalliopi N Manola
Journal:  Eur J Haematol       Date:  2009-06-25       Impact factor: 2.997

3.  Treatment strategies and long-term results in paediatric patients treated in four consecutive AML-BFM trials.

Authors:  U Creutzig; M Zimmermann; J Ritter; D Reinhardt; J Hermann; G Henze; H Jürgens; H Kabisch; A Reiter; H Riehm; H Gadner; G Schellong
Journal:  Leukemia       Date:  2005-12       Impact factor: 11.528

4.  Induction mortality and resource utilization in children treated for acute myeloid leukemia at free-standing pediatric hospitals in the United States.

Authors:  Marko Kavcic; Brian T Fisher; Yimei Li; Alix E Seif; Kari Torp; Dana M Walker; Yuan-Shung Huang; Grace E Lee; Sarah K Tasian; Marijana Vujkovic; Rochelle Bagatell; Richard Aplenc
Journal:  Cancer       Date:  2013-02-21       Impact factor: 6.860

5.  Long-term results of children with acute myeloid leukemia: a report of three consecutive Phase III trials by the Children's Cancer Group: CCG 251, CCG 213 and CCG 2891.

Authors:  F O Smith; T A Alonzo; R B Gerbing; W G Woods; R J Arceci
Journal:  Leukemia       Date:  2005-12       Impact factor: 11.528

6.  Cathepsins B and L in peripheral blood mononuclear cells of pediatric acute myeloid leukemia: potential poor prognostic markers.

Authors:  Misti Jain; Sameer Bakhshi; Abhay A Shukla; Shyam S Chauhan
Journal:  Ann Hematol       Date:  2010-06-22       Impact factor: 3.673

7.  Childhood acute myeloid leukemia: an Indian perspective.

Authors:  Ketan Prasad Kulkarni; Ram Kumar Marwaha
Journal:  Pediatr Hematol Oncol       Date:  2011-01-08       Impact factor: 1.969

8.  Early deaths and treatment-related mortality in children undergoing therapy for acute myeloid leukemia: analysis of the multicenter clinical trials AML-BFM 93 and AML-BFM 98.

Authors:  Ursula Creutzig; Martin Zimmermann; Dirk Reinhardt; Michael Dworzak; Jan Stary; Thomas Lehrnbecher
Journal:  J Clin Oncol       Date:  2004-11-01       Impact factor: 44.544

9.  Treatment strategy and results in children treated on three Dutch Childhood Oncology Group acute myeloid leukemia trials.

Authors:  G Kardos; C M Zwaan; G J L Kaspers; S S N de-Graaf; E S J M de Bont; A Postma; J P M Bökkerink; R S Weening; A van der Does-van den Berg; E R van Wering; C Korbijn; K Hählen
Journal:  Leukemia       Date:  2005-12       Impact factor: 11.528

10.  Outpatient consolidation chemotherapy in pediatric acute myeloid leukemia: a retrospective analysis.

Authors:  Sameer Bakhshi; Preetpaul Singh; Chetanya Swaroop
Journal:  Hematology       Date:  2009-10       Impact factor: 2.269
  10 in total
  6 in total

1.  Pediatric Acute Myeloid Leukemia: Improved Survival Rates in India.

Authors:  Rachna Seth; Nivedita Pathak; Amitabh Singh; Anita Chopra; Rajive Kumar; M Kalaivani
Journal:  Indian J Pediatr       Date:  2016-11-10       Impact factor: 1.967

2.  Surveillance Stool Culture and its Association with Microbiologically Documented Infection During Febrile Neutropenia in Patients with Acute Leukemia (AL) Undergoing Induction Chemotherapy.

Authors:  Naresh Jadhav; Jharna Mandal; Smita Kayal; Jogamaya Pattnaik; Ponraj Madasamy; Jagdeep Singh; Biswajit Dubashi
Journal:  Indian J Hematol Blood Transfus       Date:  2020-11-09       Impact factor: 0.915

Review 3.  Acute leukemia in children: A review of the current Indian data.

Authors:  Ramandeep Singh Arora; Brijesh Arora
Journal:  South Asian J Cancer       Date:  2016 Jul-Sep

4.  Two-drug versus three-drug induction chemotherapy in pediatric acute myeloid leukemia: a randomized controlled trial.

Authors:  Venkatraman Radhakrishnan; Sameer Bakhshi; Smita Kayal; Cherian Thampy; Ankit Batra; Praveen Kumar Shenoy; Hemanth Kumar; Swaminathan Rajaraman; Shilpi Chaudhary; Reema Bisht; Biswajit Dubashi; Trivadi S Ganesan
Journal:  Blood Cancer J       Date:  2022-09-06       Impact factor: 9.812

5.  Outcomes of pediatric acute myeloid leukemia treatment in Western Kenya.

Authors:  Romy E van Weelderen; Festus Njuguna; Kim Klein; Saskia Mostert; Sandra Langat; Terry A Vik; Gilbert Olbara; Martha Kipng'etich; Gertjan J L Kaspers
Journal:  Cancer Rep (Hoboken)       Date:  2021-11-22

6.  Epidemiological evaluation and survival of children with acute myeloid leukemia.

Authors:  Rahuany Velleda de Morais; Meriene Viquetti de Souza; Klerize Anecely de Souza Silva; Pablo Santiago; Marcelo Cunha Lorenzoni; Cecília Fernandes Lorea; Cláudio Galvão de Castro Junior; Adriano Nori Rodrigues Taniguchi; Fernanda Fetter Scherer; Mariana Bohns Michalowski; Liane Esteves Daudt
Journal:  J Pediatr (Rio J)       Date:  2020-04-20       Impact factor: 2.990
  6 in total

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