The effect of maternal Naja nigricollis envenomation on the placenta. An experimental study.

The effect of maternal envenomation with N. nigricollis venom on the placental tissues was studied in mice. The venom seemed to exert a direct toxic effect on the constituent parts of the placenta. Glycogen appeared to advantage in the cells of the trophospongeal part of the placenta. Giant cells and basophilic cells were encountered around such glycogen cells. However, some giant cells showed vacuolation of the cytoplasm and pyknosis of the nuclei. The labyrinthine part of the placenta showed large and multiple small thrombi and congestion of the blood spaces. Again glycogen appeared to advantage in the syncytial cells. Non cellular exudate was also met with in such cases. The possible mechanisms of these changes were discussed.