Haibo Li1, Qiuxia Li2, Chen Ji3, Jieruo Gu2. 1. a Third Affiliated Hospital of Sun Yat-sen University, General Hospital of Ningxia Medical University , Department of Rheumatology , Yinchuan , China. 2. b Third Affiliated Hospital of Sun Yat-sen University , Department of Rheumatology , Guangzhou , China. 3. c General Hospital of Ningxia Medical University , Department of Rheumatology , Yinchuan , China.
Abstract
PURPOSE: To investigate the correlation between clinical features of ankylosing spondylitis (AS) and different human leukocyte antigen (HLA)-B27 subtypes. METHODS: We conducted a cross-sectional study of 216 patients with AS. HLA-B27 and its subtypes were detected by polymerase chain reaction with sequence specific primer (PCR-SSP). Clinical features were compared between the different HLA-B27 subtypes. A meta-analysis on uveitis frequencies in AS patients with HLA-B*2705 vs 2704 was performed. RESULTS: The most prevalent subtypes of HLA-B27 were HLA-B*2704 (66.1%) and HLA-B*2705 (32.2%). There were 57 HLA-B27-positive AS patients with the history of uveitis; 45 were B*2704 and 12 were B*2705. Patients with B*2704 had more uveitis than B*2705 (p = 0.021). After meta-analysis, there was no significant difference in the presence of uveitis between HLA-B*2704 and HLA-B*2705. CONCLUSIONS: AS patients with B*2704 have a higher risk of uveitis than AS with B*2705 in a north Chinese people.
PURPOSE: To investigate the correlation between clinical features of ankylosing spondylitis (AS) and different humanleukocyte antigen (HLA)-B27 subtypes. METHODS: We conducted a cross-sectional study of 216 patients with AS. HLA-B27 and its subtypes were detected by polymerase chain reaction with sequence specific primer (PCR-SSP). Clinical features were compared between the different HLA-B27 subtypes. A meta-analysis on uveitis frequencies in AS patients with HLA-B*2705 vs 2704 was performed. RESULTS: The most prevalent subtypes of HLA-B27 were HLA-B*2704 (66.1%) and HLA-B*2705 (32.2%). There were 57 HLA-B27-positive AS patients with the history of uveitis; 45 were B*2704 and 12 were B*2705. Patients with B*2704 had more uveitis than B*2705 (p = 0.021). After meta-analysis, there was no significant difference in the presence of uveitis between HLA-B*2704 and HLA-B*2705. CONCLUSIONS: AS patients with B*2704 have a higher risk of uveitis than AS with B*2705 in a north Chinese people.
Authors: Sari H Rytkönen; Petri Kulmala; Helena Autio-Harmainen; Pekka Arikoski; Kira Endén; Janne Kataja; Tuomo Karttunen; Matti Nuutinen; Timo Jahnukainen Journal: Pediatr Nephrol Date: 2017-09-11 Impact factor: 3.714
Authors: Ariana Barbera Betancourt; Qingkang Lyu; Femke Broere; Alice Sijts; Victor P M G Rutten; Willem van Eden Journal: Front Immunol Date: 2017-10-26 Impact factor: 7.561