Vishal Bali1, Satabdi Chatterjee2, Michael L Johnson2, Hua Chen2, Ryan M Carnahan3, Rajender R Aparasu2. 1. Senior Health Outcomes Researcher, Health Advocate, Westlake Village, CA, USA. 2. Department of Pharmaceutical Health Outcomes & Policy, College of Pharmacy, University of Houston, Texas Medical Center, 1441 Moursund Street, Houston, TX 77030-3407, USA. 3. Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA, USA.
Abstract
AIM: To evaluate comparative safety of paroxetine and other selective serotonin reuptake inhibitors (SSRIs) for the risk of hip fractures. PATIENTS & METHODS: A propensity score-matched retrospective cohort study was conducted using 2007-2010 Minimum Data Set linked Medicare data. Robust Cox proportional hazards model was used to evaluate the risk of hip fractures in depressed elderly nursing home residents. RESULTS: Cox analysis did not find any significant difference in the risk of hip fractures for the paroxetine users (hazard ratio: 1.09; 95% CI: 0.91-1.32) when compared with other SSRIs. Results from the sensitivity analysis supported the main findings. CONCLUSION: There was no differential risk of hip fractures between paroxetine and other SSRIs. Future studies are needed to evaluate other anticholinergic effects of paroxetine.
AIM: To evaluate comparative safety of paroxetine and other selective serotonin reuptake inhibitors (SSRIs) for the risk of hip fractures. PATIENTS & METHODS: A propensity score-matched retrospective cohort study was conducted using 2007-2010 Minimum Data Set linked Medicare data. Robust Cox proportional hazards model was used to evaluate the risk of hip fractures in depressed elderly nursing home residents. RESULTS: Cox analysis did not find any significant difference in the risk of hip fractures for the paroxetine users (hazard ratio: 1.09; 95% CI: 0.91-1.32) when compared with other SSRIs. Results from the sensitivity analysis supported the main findings. CONCLUSION: There was no differential risk of hip fractures between paroxetine and other SSRIs. Future studies are needed to evaluate other anticholinergic effects of paroxetine.
Entities:
Keywords:
Medicare; SSRIs; comparative effectiveness; comparative risk; depression; elderly; hip fracture; nursing home residents; paroxetine; selective serotonin reuptake inhibitors
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