Samir Delibegovic1,2, Anhel Koluh3, Elmir Cickusic2,4, Muhamed Katica5, Jasminka Mustedanagic4, Ferid Krupic6. 1. a Department of Surgery , University Clinical Centre , Tuzla , Bosnia and Herzegovina. 2. b Faculty of Medicine , University of Tuzla , Tuzla, Bosnia and Herzegovina. 3. c Cantonal Hospital Zenica , Tuzla, Bosnia and Herzegovina. 4. d Clinic for Pathology, University Clinical Centre , Tuzla , Bosnia and Herzegovina. 5. e Veterinary Faculty , University of Sarajevo , Tuzla, Bosnia and Herzegovina. 6. f Department of Orthopaedics, Institute of Clinical Sciences , Sahlgrenska Academy, University of Gothenburg , Gothenburg , Sweden.
Abstract
BACKGROUND: After laparoscopic repair of an incisive hernia, intraperitoneal prosthetic mesh, as a foreign material, is a strong stimulus for the development of adhesion, which may be the cause of serious complications. This experimental study compared three different meshes and their ability to prevent the formation of adhesion and shrinkage. METHODS: Ninety rats were divided randomly into three groups: in Group 1 Proceed mesh was implanted, in Group 2 Ultrapro mesh was implanted, and in Group 3 TiMesh was implanted. Mesh samples were fixed as an intraabdominal mesh in the upper part of the abdomen. Ten animals from each group were sacrificed on days 7, 28 and 60 post-surgery. After opening the abdomen, the formation of adhesion was assessed according to the Surgical Membrane Study Group (SMSG) score, the percentage of shrinkage of the mesh was established and inflammatory reaction scored. RESULTS: The SMSG score for adhesion was statistically significantly higher on all the postoperative days in the Proceed and Ultrapro mesh groups than in the TiMesh group which caused milder inflammatory reaction on 60th day than others meshes. The size of the mesh after 7 days was statistically significantly smaller in the Proceed and Ultrapro groups than in the TiMesh group, but after 60 days it was statistically significantly larger than in the TiMesh group. CONCLUSION: The least formation of adhesion was noted in the TiMesh group, in which the highest level of shrinkage was noticed after 28 and 60 days. TiMesh has advantages over the other meshes studied, but a larger size mesh may be recommended for intraperitoneal application.
BACKGROUND: After laparoscopic repair of an incisive hernia, intraperitoneal prosthetic mesh, as a foreign material, is a strong stimulus for the development of adhesion, which may be the cause of serious complications. This experimental study compared three different meshes and their ability to prevent the formation of adhesion and shrinkage. METHODS: Ninety rats were divided randomly into three groups: in Group 1 Proceed mesh was implanted, in Group 2 Ultrapro mesh was implanted, and in Group 3 TiMesh was implanted. Mesh samples were fixed as an intraabdominal mesh in the upper part of the abdomen. Ten animals from each group were sacrificed on days 7, 28 and 60 post-surgery. After opening the abdomen, the formation of adhesion was assessed according to the Surgical Membrane Study Group (SMSG) score, the percentage of shrinkage of the mesh was established and inflammatory reaction scored. RESULTS: The SMSG score for adhesion was statistically significantly higher on all the postoperative days in the Proceed and Ultrapro mesh groups than in the TiMesh group which caused milder inflammatory reaction on 60th day than others meshes. The size of the mesh after 7 days was statistically significantly smaller in the Proceed and Ultrapro groups than in the TiMesh group, but after 60 days it was statistically significantly larger than in the TiMesh group. CONCLUSION: The least formation of adhesion was noted in the TiMesh group, in which the highest level of shrinkage was noticed after 28 and 60 days. TiMesh has advantages over the other meshes studied, but a larger size mesh may be recommended for intraperitoneal application.
Authors: Paulo Vicente Dos Santos Filho; Rafael Silva Santos; Sydney Correia Leão; Ivisson Xavier Duarte; Sonia Oliveira Lima Journal: Acta Cir Bras Date: 2021-01-20 Impact factor: 1.388
Authors: Islam Khaled; Pablo Priego; Mohammed Faisal; Marta Cuadrado; Francisca García-Moreno; Araceli Ballestero; Julio Galindo; Eduardo Lobo Journal: BMC Surg Date: 2019-10-28 Impact factor: 2.102