Prevalence and Self-recognition of Chronic Constipation: Results of an Internet Survey.

BACKGROUND/AIMS: Although chronic constipation is a common symptom, to date no international consensus has been reached regarding its definition. The aims of this study were (1) to investigate defecation habits and (2) to examine the prevalence of constipation using the Japanese Society of Internal Medicine (JSIM) and the Rome III criteria using an online survey.
METHODS: An online questionnaire composed of items on the frequency, interval, form of defecation, the management, and self-recognition of constipation (reference standard of constipation) was created. A total of 5155 valid responses were received. In addition, constipation symptoms were evaluated through a survey using the JSIM and the Rome III criteria.
RESULTS: In the internet survey, 28.4% of the respondents considered themselves to be constipated. Stratified by sex, significantly more females (37.5%) than males (19.1%) considered themselves to be constipated (P < 0.001). The prevalence of constipation among the respondents was 28.0% using the Rome III, but only 10.1% using the JSIM. The diagnostic accuracy was 73.2% for the Rome III and 78.1% for the JSIM, while the diagnostic specificity was 81.1% for the Rome III and 97.5% for the JSIM. However, the diagnostic sensitivities for both measures were low, at 52.2% and 29.2% for the Rome III and the JSIM, respectively.
CONCLUSIONS: The online survey developed for this study was able to provide clarification regarding defecation patterns. The results also suggest a discrepancy between the self-recognized prevalence of constipation in Japan and prevalence of constipation based on the JSIM criteria.

Introduction

Chronic constipation is a condition frequently encountered in the clinical setting.1–4 However, the definition and understanding of constipation vary widely among individuals, and in some cases, by region.5–8 The prevalence of constipation based on the Rome III criteria has been reported at varying levels around the world, from 8.2% to 32.9%.9–17 In Asian countries such as China, Korea, Hong Kong, and India, the prevalence of constipation reportedly ranges from 8.2% to 16.8%.9,10,12,13 However, little epidemiological information regarding defecation habits and the prevalence of constipation in Japan is currently available.

Epidemiological surveys conducted by conventional techniques are becoming more difficult to carry out due to enhanced protection of personal privacy. However, an epidemiological internet survey can provide a great deal of data without requiring individuals to identify themselves. In fact, according to the recent Communications Usage Trend Survey by the Japanese Ministry of Internal Affairs and Communications (MIC), over 100 million Japanese citizens now have access to and frequently use the internet. Furthermore, because the sample population chosen for participation in an internet survey can be selected to be representative of the Japanese population as a whole, the results are expected to be highly reliable predictors of the actual situation in Japan.

Therefore, we conducted an internet survey (1) to investigate the defecation habits and attitudes toward constipation in Japan, and (2) to examine the prevalence of constipation based on the Japanese Society of Internal Medicine (JSIM) and the Rome III criteria.

Materials and Methods

Internet Questionnaire Survey

With the cooperation of an internet research company (Macromill, Inc, Tokyo, Japan), we conducted an internet questionnaire survey in August 2014 targeting males and females of the general Japanese population aged 20 to 79 years. We hoped to collect data from approximately 5000 respondents; therefore, we asked a total of 15 000 individuals to participate. Respondents who failed to completely answer the questions were excluded from the analysis. A total of 5155 subjects (2542 males and 2613 females) who completed the questionnaire were finally enrolled. Male and female subjects in each age group (20 to < 30 years, 20’s; 30 to < 40 years, 30’s; 40 to < 50 years, 40’s; 50 to < 60 years, 50’s; 60 to < 70 years, 60’s; and 70 to < 80 years, 70’s) were selected from among the registered panelists based on Japanese demographics (Table 1). The respondents in this study were assigned to groups on the internet in reference to the population ratio in Japan by generation and sex according to the national census conducted by the MIC Statistics Bureau (2010).

Table 1

Characteristics of the Subjects

Age group	20–29 yr	30–39 yr	40–49 yr	50–59 yr	60–69 yr	70–79 yr	Total
Number (M/F)	367/355	490/476	453/445	437/442	479/509	316/386	2542/2613
Age (M/F), mean ± SD (yr)	24.9 ± 2.8/25.3 ± 2.8	35.1 ± 2.9/34.8 ± 2.9	44.6 ± 2.8/44.3 ± 2.8	54.0 ± 2.8/53.9 ± 2.8	64.1 ± 2.6/63.8 ± 2.5	73.2 ± 2.7/72.9 ± 2.6	48.8 ± 15.9/49.6 ± 16.0

Questionnaire Items

We developed an original questionnaire to diagnose constipation in accordance with the Rome III (Japanese version) and the JSIM criteria.18 The questionnaire was composed of 13 items regarding defecation habits and actual status. The questionnaire items are shown in the Appendix. The participants were asked about their recognition of constipation, frequency of defecation, stool appearance, typical defecation interval, and if they had symptoms that met the diagnostic criteria for irritable bowel syndrome (IBS).19–21 Self-recognition of constipation was set as the reference standard of constipation in this study. We also asked respondents who recognized themselves as being constipated about how they managed their constipation.

Statistical Methods

All results are expressed as mean ± standard deviation. The data were assessed by the Mann-Whitney U-test and Fisher’s exact test. Statistical significance was defined as P < 0.05.

Results

Actual Status of Defecation-related Issues in Japan (Frequency of Defecation, Stool Appearance, Sense of Incomplete Defecation, Sense of Difficult Defecation)

The mean overall frequency of defecations per week was 6.9 ± 4.2. A total of 8.4% of all respondents reported that they defecated less than twice a week, and 25.0% reported that they defecated more than 8 times a week (Fig. 1A). Stratified by sex, the mean was significantly lower in females (5.9 ± 3.4) than in males (7.9 ± 4.7) (P < 0.001) (Fig. 1B). Stratification by age produced no significant differences between age groups in men. Females in their 20’s had the lowest mean frequency of defecations per week (5.1 ± 2.8), with this frequency increasing significantly with increasing age.

Figure 1

Actual status of defecation-related issues. (A) Frequency of defecations per week among the respondents (n = 5155). (B) Number of defecations per week in each sex.

Stool appearance was defined using the Bristol scale, with values of 1 or 2 considered to be “hard” stool, 3, 4, and 5 considered to be “normal”, and 6 and 7 considered to be “soft”.22–24 Among all respondents, the prevalence of “hard”, “normal”, and “soft” stool was 19.3% (997/5155), 67.6% (3483/5155), and 13.1% (674/5155), respectively. Significantly more females (652/2613; 25.0%) than males (345/2542; 13.6%) reported having hard stool. The frequency of hard stool in females increased significantly with younger age. Among respondents with “hard stool”, 51.1% (509/997) were diagnosed as having functional constipation (FC) and 16.0% (160/997) as IBS with constipation (IBS-C).

A sense of incomplete defecation was reported by 36.5% (1879/5155) of the respondents, and a sense of difficult defecation (straining at stool, sensation of blockage, and use of measures such as pressing the abdomen during defecation) was reported by 54.8% (2827/5155).

Perceptions of Constipation

Constipation was only considered to be a medical condition by approximately half (48.8%) of the respondents. When asked what constitutes constipation, the largest number of respondents (3644/5155; 70.7%) replied, “Unable to defecate without medication.” The next most common response (3549/5155; 68.8%) was, “Few bowel movements”, and the third and fourth most common responses were “Difficulty in defecating” (3533/5155; 68.5%) and “Hard stool” (3007/5155; 58.3%), respectively. In the respondents with self-recognized constipation, “Few bowel movements (1215/1464; 83.0%)”, “Difficulty in defecating (1124/1464; 76.8%)”, “Hard stool (1046/1464; 71.4%)”, “Unable to defecate without medication (979/1464; 66.9%)” were considered important. In contrast, in the respondents who did not consider themselves as being constipated, “Few bowel movements (2334/3691; 63.2%)”, “Difficulty in defecating (2409/3691; 65.3%)”, “Hard stool (1961/3691; 53.1%)”, and “Unable to defecate without medication (2665/3691; 72.2%)” were also considered important.

Percentage of Respondents Who Considered Themselves to Have Constipation

A total of 28.4% (1464/5155) of the respondents thought that they had constipation (Fig. 2A). When stratified by sex, significantly more females (979/2613; 37.5%) than males (485/2542; 19.1%) thought that they had constipation (P < 0.001) (Fig. 2B). When stratified by sex and age group, no significant differences between age groups were noted in men. The percentage of women who considered themselves to have constipation increased with younger age (P < 0.001). In the respondents with “hard stool”, 68.9% (687/997) thought that they had constipation.

Figure 2

Percentage of respondents who considered themselves as being constipated (n = 5155). (A) Prevalence of self-recognition of constipation. (B) Ratio of self-recognition of constipation in each sex.

Differences in Stool Characteristics among Respondents with and Without Self-recognized Constipation

The respondents who considered themselves as being constipated reported a mean of 4.2 bowel movements per week, compared with 8.0 among those who did not (P < 0.001) (Fig. 3A). The frequency of hard stool was 46.9% and 8.4%, respectively (P < 0.001) (Fig. 3B). The ratio of respondents who reported experiencing a sense of incomplete defecation was 70.3% and 23.0%, respectively (P < 0.001) (Fig. 3C).

Figure 3

Differences in stool characteristics with and without self-recognized constipation. (A) Frequency of defecations per week in respondents with (+) and without self-recognized constipation (−). (B) Ratio of hard stool (Bristol stool forms 1 and 2). (C) Sense of incomplete defecation.

Management of Constipation

Increased water intake was the most commonly held idea as a countermeasure against constipation (52.2%, 2693/5155 respondents). The next most common idea was to get more sleep (39.7%), followed by changes in diet (38.6%), use of a bidet-toilet (37.1%), reduction of stress (31.0%), and exercise (25.3%). Over-the-counter oral medicines were used by 7.9%. Only a few respondents (4.7%) had seen a doctor for their condition. Most of the males and females who saw a doctor for constipation were elderly (Fig. 4).

Figure 4

Constipation management (n = 5155). OTC, over the counter.

Prevalence of Constipation in the Japanese Population According to the Rome III and Japanese Society of Internal Medicine Criteria

A total of 28.0% (1445/5155) of the respondents were classified as having FC based on the Rome III criteria. In contrast, only 10.1% (520/5155) met the criteria for constipation as defined by the JSIM.

Of the respondents who considered themselves as being constipated, 52.2% (764/1464) and 29.2% (428/1464) met the Rome III and JSIM diagnostic criteria, respectively. The diagnostic ratio according to the Rome III and JSIM criteria is shown in Table 2. The diagnostic accuracy was 73.2% and 78.1% for the Rome III and JSIM criteria, respectively, while the diagnostic specificity was 81.5% and 97.5 % for the Rome III and JSIM criteria, respectively. However, the diagnostic sensitivity was low for both measures, at 52.2% and 29.2%, respectively.

Table 2

Diagnostic Accuracy Between the Definitions by the Japanese Society of Internal Medicine and the Rome III Criteria

	Sensitivity	Specificity	Accuracy	PPV	NPV
JSIM	0.292	0.975	0.781	0.823	0.776
Rome III	0.522	0.815	0.732	0.529	0.811

PPV, positive predictive value; NPV, negative predictive value; JSIM, the Japanese Society of Internal Medicine.

The Subtype of the Subjects with Self-recognized Constipation

Approximately half (52.2%, 764/1464) of the respondents with self-recognized constipation were diagnosed as having FC, one-quarter (23.8%; 9.5% IBS-C, 6.7% mixed IBS, 4.3% IBS with diarrhea, and 3.3% unsubtyped IBS) were diagnosed with IBS, and the remainder (24.0%) were diagnosed with another condition (Fig. 5). All participants (100%, 1455/1455) with IBS-C responded as having Bristol scale stool forms 1 and 2; however, only one third (35.2%) of those with FC responded as having Bristol scale stool forms 1 and 2.

Figure 5

The subtypes of respondents with self-recognized constipation. FC, functional constipation; IBS, irritable bowel syndrome; IBS-U, unsubtyped IBS; IBS-D, IBS with diarrhea; IBS-C, IBS with constipation; IBS-M, mixed IBS.

Discussion

Constipation is characterized by infrequent bowel movements or difficulty in defecation. Constipation is generally diagnosed from symptoms such as a reduced number of weekly bowel movements, hard stool, a sense of incomplete defecation or a sense of difficult defecation.25–28 However, constipation is recognized differently among individuals, regions, and cultures.5–8 Therefore, in order to investigate the actual status of constipation in Japan, it is first necessary to clearly understand how Japanese people conceptualize constipation and their defecation habits. For this purpose, we conducted an internet survey to investigate how constipation was recognized among Japanese people. Our results clearly showed that only about half of the respondents considered constipation to be a medical condition. This situation was evidenced by the fact that the most common countermeasures among respondents who developed constipation were lifestyle adjustments such as drinking more water, getting more sleep, and changing their diet. Only 4.7% of the respondents actually visited their doctor for constipation.

When we investigated defecation habits, we found that respondents reported a mean of 6.9 bowel movements per week. The most common range (66.5% of respondents) was 3–7 bowel movements per week, while a relatively small number had 0–2 movements per week. When asked about stool appearance, most of the responders reported normal stool, and 19.3% reported lumpy or hard stool. Moreover, a sense of incomplete defecation was reported by 36.5% of the respondents, and a sense of difficult defecation (straining, sensation of anorectal obstruction/blockage, or manual maneuvers) was reported by 54.8%. These are valuable data since no detailed information concerning actual defecation habits in Japan has been available to date.

So what constitutes constipation in the opinion of the Japanese people? To answer this question, we compared the characteristics of defecation in respondents who considered themselves to be constipated with those who did not. Among the respondents who had no more than two bowel movements per week, approximately 80% considered themselves to be constipated. With regard to defecation characteristics, we found that 68.9% of the respondents with hard stool and 70.3% of those who had a sense of incomplete defecation thought that they were constipated. These findings suggest that the number of bowel movements, the hardness of stool, and a sense of incomplete defecation are all associated with constipation. In both respondents with and without self-recognized constipation, few bowel movements, difficulty in defecating, hard stool, and unable to defecate without medication were most important senses of constipation. These results indicate that individuals only consider themselves to be constipated when they have a combination of conditions, as opposed to any one specific characteristic.

This present study allows us to evaluate whether constipation is appropriately defined in Japan. A wide variety of definitions of constipation are used around the world, several of which are used in Japan.29–31 For example, the JSIM defines constipation as “3 or more days without a bowel movement, or a sense of incomplete defecation after daily bowel movements”. On the international level, the Rome III criteria are widely used as a definition of functional constipation.32 These criteria require that symptoms have occurred over the previous 6 months, that for the previous 3 months the subject has experienced less than three bowel movements per week and/or symptoms of straining during defecation, hard stool, sense of incomplete defecation, or sense of difficult defecation at least once every four bowel movements, and that the subject does not meet the diagnostic criteria for IBS. However, it is difficult to distinguish between the FC as defined by the Rome III criteria and IBS-C. In the present study, among approximately half of the respondents with self-recognized constipation who were diagnosed as having FC, 23.8% were diagnosed as having IBS. These results indicate the possibility of overlap, and some reports have even suggested that FC and IBS-C are the same condition.33–36

To date, there is no standard definition of constipation. In this survey, using the personal judgment of the respondents as the “gold standard”, we assessed the diagnostic accuracy of the definitions of constipation according the Rome III and the JSIM criteria. As a result, no major differences were observed between these definitions in diagnostic accuracy (73.2% vs 78.1%, respectively). However, the JSIM definition provided a diagnostic sensitivity of 29.2%, which was considerably lower than the 52.2% for the Rome III. The relatively low sensitivity of the JSIM may be attributed to the fact that the definition of constipation included only the prevalence of bowel movements and a sense of incomplete defecation, while omitting stool hardness and a sense of difficult defecation such as straining, sensation of anorectal obstruction/blockage, and manual maneuvers. The relatively low sensitivity (52.2%) of the Rome III criteria may be attributed to the fact that, although this classification uses a multi-sided definition of constipation (number of bowel movements, hardness of stool, sense of incomplete defecation, sense of difficult defecation, etc), some patients with constipation may instead be diagnosed with IBS. In fact, 23.8% of the respondents who felt constipated were diagnosed as having IBS. Specificity was 97.5% for the JSIM criteria, which was markedly higher than the 81.5% for the Rome III criteria, although both values were high. This may be because the JSIM criteria have few diagnostic items, which resulted in diagnosing a narrower range of patients. If the Rome III definition was applied to all respondents, 28.0% of the Japanese population would be considered to have constipation, whereas if the JSIM definition was applied, that number would be 10.1%.

In the present study, the prevalence of respondents who reported being constipated was close to the percentage suggested by the Rome III definition. In Asian countries, the prevalence of constipation is reportedly about 8% to 17%.9,10,12,13 These differences may have been because the study methodologies and backgrounds of the enrolled subjects were different. Moreover, it should be noted that constipation was diagnosed by the Rome III definition in only half of the respondents who self-identified as having constipation. As shown in Figure 5, under the Rome III criteria, 23.8% of the respondents who reported being constipated would be classified as having IBS, and the remaining respondents were diagnosed with other conditions. In other words, these people were not aware that they had IBS. Further study of IBS in Japan is warranted.

We conducted this research on the internet. As previously described, this method involves a number of issues, including the completion rate. The completion rate of enrolled subjects in this study was about 30%; although this was not very high, it is in line with the average completion rate of respondents in internet surveys. Moreover, this methodology is limited to internet users, and therefore may only collect data from a specific stratum of subjects, does not guarantee that the survey was actually completed by the subject, and cannot exclude the possibility that subjects might provide casual answers. However, the importance of protecting personal information has become more widely recognized in recent years, which has made it increasingly difficult to conduct large-scale epidemiological studies. In addition, based on communication dynamics research by the MIC 2014, internet users represent about 80% of the Japanese population. In addition, the internet offers the advantage of obtaining data from respondents aged 20 to 80 years stratified by various characteristics such as sex, age, and regional distribution. Therefore, the results can still be considered credible.

The limitation of this study was the lack of validation of the questionnaire. In the present study, we developed an original questionnaire in accordance with the Rome III and the JSIM criteria. In addition, as the present study was a questionnaire survey for the general population, we could not rule out the inclusion of a variety of conditions in addition to FC (chronic idiopathic constipation), including organic constipation, drug-induced constipation, and constipation secondary to underlying disease. Moreover, we also cannot be sure whether the self-recognition of constipation was referring to chronic constipation or recent constipation.

However, because the survey involved very large sample size of more than 5000 respondents based on Japanese demographics, the findings may still provide useful information regarding the awareness and actual situation of constipation in Japan.

In conclusion, our results clarified (1) defecation habits in Japan, and (2) identified a discrepancy between the prevalence of self-recognized constipation and that based on the JSIM criteria.