| Literature DB >> 27424656 |
James D Firth1, Philip G E Craven1, Matthew Lilburn1, Axel Pahl2, Stephen P Marsden1, Adam Nelson3.
Abstract
A synthetic approach to diverse scaffolds was developed that was inspired by diterpene biosynthesis. Initial scaffolds, generated using Diels-Alder reactions of furyl-functionalised amines, were transformed into alternative scaffolds using cleavage, ring expansion, annulation and rearrangement reactions. In total, 25 diverse scaffolds were prepared that were shown to have high natural product-likeness.Entities:
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Year: 2016 PMID： 27424656 DOI： 10.1039/c6cc04662b
Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222