Literature DB >> 27424599

Urinary micafungin levels are sufficient to treat urinary tract infections caused by Candida spp.

S Grau1, S Luque2, D Echeverría-Esnal2, L Sorlí3, N Campillo2, M Montero4, F Álvarez Lerma5, V Plasencia6, J P Horcajada7.   

Abstract

Six cases of patients diagnosed with urinary tract infection (UTI) successfully treated with micafungin are reported. Four were infected with fluconazole-resistant Candida spp. and two (with hepatic injury) were infected with fluconazole-sensitive Candida spp. Traditionally, echinocandins have not been considered for the treatment of UTIs. However, despite its low urinary excretion rate, therapeutic drug monitoring of micafungin urinary levels could be helpful in order to achieve optimal pharmacokinetic/pharmacodynamic (PK/PD) indices for treating UTIs caused by Candida spp. resistant to fluconazole.
Copyright © 2016 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.

Entities:  

Keywords:  Candida spp; Fluconazole-resistant; Micafungin; Urinary tract infection

Mesh：

Substances：

Year:  2016        PMID： 27424599     DOI： 10.1016/j.ijantimicag.2016.05.010

Source DB:  PubMed          Journal:  Int J Antimicrob Agents        ISSN： 0924-8579            Impact factor:   5.283


  5 in total

1.  A Rare Case of Urinary Tract Fungal Ball Leading to Fungemia and Bilateral Chorioretinitis.

Authors:  Christopher Ferari; Chad Crigger; Chad Morley
Journal:  Case Rep Urol       Date:  2020-09-28

2.  Outcomes of caspofungin use in the treatment of Candida-related urinary tract infections, a case series.

Authors:  Laila Rkieh; Wasim S El Nekidy; Leen Oyoun Alsoud; Adnan Alatoom; Rania El Lababidi; Mohamad Mooty; Ahmad R Nusair
Journal:  IDCases       Date:  2022-05-18

Review 3.  Administration and Dosing of Systemic Antifungal Agents in Pediatric Patients.

Authors:  Kevin J Downes; Brian T Fisher; Nicole R Zane
Journal:  Paediatr Drugs       Date:  2020-04       Impact factor: 3.022

4.  A Phase 3 Study of Micafungin Versus Amphotericin B Deoxycholate in Infants With Invasive Candidiasis.

Authors:  Daniel K Benjamin; David A Kaufman; William W Hope; P Brian Smith; Antonio Arrieta; Paolo Manzoni; Laura L Kovanda; Christopher Lademacher; Brigit Isaacson; Deborah Jednachowski; Chunzhang Wu; Atsunori Kaibara; Thomas J Walsh
Journal:  Pediatr Infect Dis J       Date:  2018-10       Impact factor: 2.129

5.  Bittersweet: infective complications of drug-induced glycosuria in patients with diabetes mellitus on SGLT2-inhibitors: two case reports.

Authors:  Caroline Bartolo; Victoria Hall; N Deborah Friedman; Chloe Lanyon; Andrew Fuller; C Orla Morrissey; Eugene Athan
Journal:  BMC Infect Dis       Date:  2021-03-20       Impact factor: 3.090
  5 in total

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