Kensuke Yamauchi1, Shinnosuke Nogami2, Gerardo Martinez-de la Cruz2, Bunichi Hirayama2, Yoshinaka Shimizu3, Hiroyuki Kumamoto3, Bernd Lethaus4, Peter Kessler5, Tetsu Takahashi2. 1. Division of Oral and Maxillofacial Surgery, Department of Oral Medicine and Surgery, Graduate School of Dentistry, Tohoku University, Japan. Electronic address: yamaken@dent.tohoku.ac.jp. 2. Division of Oral and Maxillofacial Surgery, Department of Oral Medicine and Surgery, Graduate School of Dentistry, Tohoku University, Japan. 3. Division of Oral Pathology, Department of Oral Medicine and Surgery, Graduate School of Dentistry, Tohoku University, Japan. 4. Department of Oral and Maxillofacial Surgery, RWTH Aachen University, Germany. 5. Department of Cranio-Maxillofacial Surgery, Maastricht University Medical Center, The Netherlands.
Abstract
UNLABELLED: This study aimed to improve bone regeneration using a timed-release system for periosteal expansion osteogenesis (TIME-PEO) using a shape memory alloy (SMA) mesh device and absorbable thread in a rabbit model. MATERIALS AND METHODS: Twelve rabbits were used in this study. The device was inserted under the periosteum at the forehead, then pushed, bent, and attached to the bone surface and fixed with an absorbable thread. Rabbits were divided into groups C1 (5 weeks postoperatively without dynamic elevation), C2 (8 weeks postoperatively without dynamic elevation), T1 (5 weeks postoperatively from TIME-PEO), and T2 (8 weeks postoperatively from TIME-PEO). Newly formed bone was evaluated histologically and radiographically. RESULTS: The newly formed bone volume to elevated bone volume ratio was 6.1% in C1, 21.9% in T1 15.5% in C2 and 36.0% in T2. These quantitative data indicate that TIME-PEO group had a significantly higher volume than that of the control group (P < 0.05). Histologically, multiple dome-shaped bones, outlined by thin and scattered trabeculae, over the original bone surface were evident in the T group. CONCLUSION: This technique appears to be a promising clinical alternative for alveolar bone augmentation and introduces the new concept of "dynamic guided bone regeneration" for atrophic alveolar bone.
UNLABELLED: This study aimed to improve bone regeneration using a timed-release system for periosteal expansion osteogenesis (TIME-PEO) using a shape memory alloy (SMA) mesh device and absorbable thread in a rabbit model. MATERIALS AND METHODS: Twelve rabbits were used in this study. The device was inserted under the periosteum at the forehead, then pushed, bent, and attached to the bone surface and fixed with an absorbable thread. Rabbits were divided into groups C1 (5 weeks postoperatively without dynamic elevation), C2 (8 weeks postoperatively without dynamic elevation), T1 (5 weeks postoperatively from TIME-PEO), and T2 (8 weeks postoperatively from TIME-PEO). Newly formed bone was evaluated histologically and radiographically. RESULTS: The newly formed bone volume to elevated bone volume ratio was 6.1% in C1, 21.9% in T1 15.5% in C2 and 36.0% in T2. These quantitative data indicate that TIME-PEO group had a significantly higher volume than that of the control group (P < 0.05). Histologically, multiple dome-shaped bones, outlined by thin and scattered trabeculae, over the original bone surface were evident in the T group. CONCLUSION: This technique appears to be a promising clinical alternative for alveolar bone augmentation and introduces the new concept of "dynamic guided bone regeneration" for atrophic alveolar bone.
Authors: Carolina Montoya; Yu Du; Anthony L Gianforcaro; Santiago Orrego; Maobin Yang; Peter I Lelkes Journal: Bone Res Date: 2021-02-11 Impact factor: 13.567