Literature DB >> 27424000

Chemical applicability domain of the Local Lymph Node Assay (LLNA) for skin sensitization potency. Part 1. Underlying physical organic chemistry principles and the extent to which they are represented in the LLNA validation dataset.

D W Roberts1, A M Api2, G Patlewicz3, T W Schultz4.   

Abstract

Keywords:  Electrophilicity; Hydrophobicity; Reactivity; Relative Alkylation Index (RAI); Skin penetration; Skin sensitization

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Substances：

Year:  2016        PMID： 27424000     DOI： 10.1016/j.yrtph.2016.07.007

Source DB:  PubMed          Journal:  Regul Toxicol Pharmacol        ISSN： 0273-2300            Impact factor:   3.271


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  2 in total

1.  Application of Defined Approaches for Skin Sensitization to Agrochemical Products.

Authors:  Judy Strickland; James Truax; Marco Corvaro; Raja Settivari; Joseph Henriquez; Jeremy McFadden; Travis Gulledge; Victor Johnson; Sean Gehen; Dori Germolec; David G Allen; Nicole Kleinstreuer
Journal:  Front Toxicol       Date:  2022-05-02

2.  Interpretation of murine local lymph node assay (LLNA) data for skin sensitization: Overload effects, danger signals and chemistry-based read-across.

Authors:  David W Roberts
Journal:  Curr Res Toxicol       Date:  2021-01-21
  2 in total

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