Jiwon Yang1, Jin-Seok Park2, Ki-Wook Oh2, Seong-Il Oh3, Hyeon-Mi Park4, Seung Hyun Kim5. 1. Department of Neurology, Gachon University, Gil Medical Center, 21, Namdong-daero, 774 Beon-gil, Namdong-gu, Incheon 21565, South Korea. 2. Department of Neurology, College of Medicine, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul 04763, South Korea. 3. Department of Neurology, Busan Paik Hospital, Inje University, 75, Bokji-ro, Busanjin-gu, Busan 47392, South Korea. 4. Department of Neurology, Gachon University, Gil Medical Center, 21, Namdong-daero, 774 Beon-gil, Namdong-gu, Incheon 21565, South Korea. Electronic address: neurohm@gilhospital.com. 5. Department of Neurology, College of Medicine, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul 04763, South Korea. Electronic address: kimsh1@hanyang.ac.kr.
Abstract
OBJECTIVE: This study aimed to measure serum 25-hydroxyvitamin D [25(OH)D] concentrations, bone mineral density (BMD), and the parameters of bone metabolism in amyotrophic lateral sclerosis (ALS) patients, and their correlation with survival. METHODS: We retrospectively analysed data of 100 ALS patients who consecutively visited a single referral ALS clinic between January and December 2011. Sex; age and site of symptom onset; and death were recorded. Serum 25(OH)D concentration was dichotomized as <10ng/ml and ≥10ng/ml. RESULTS: There was absent relationship between serum 25(OH)D and concentration of bone turnover parameters or between 25(OH)D and BMD. According to the results of the Kaplan-Meier analysis with log-rank test, the survival rates of patients without (≥10ng/ml) and of those with severe vitamin D deficiency (< 10ng/ml) were not significantly different. Cox regression analysis showed that a poor prognosis was most correlated with older age at onset and bulbar onset after adjustment for all the clinical factors. CONCLUSIONS: In conclusion, vitamin D levels were not correlated to other bone markers and survival in a clinic population of ALS patients.
OBJECTIVE: This study aimed to measure serum 25-hydroxyvitamin D [25(OH)D] concentrations, bone mineral density (BMD), and the parameters of bone metabolism in amyotrophic lateral sclerosis (ALS) patients, and their correlation with survival. METHODS: We retrospectively analysed data of 100 ALSpatients who consecutively visited a single referral ALS clinic between January and December 2011. Sex; age and site of symptom onset; and death were recorded. Serum 25(OH)D concentration was dichotomized as <10ng/ml and ≥10ng/ml. RESULTS: There was absent relationship between serum 25(OH)D and concentration of bone turnover parameters or between 25(OH)D and BMD. According to the results of the Kaplan-Meier analysis with log-rank test, the survival rates of patients without (≥10ng/ml) and of those with severe vitamin D deficiency (< 10ng/ml) were not significantly different. Cox regression analysis showed that a poor prognosis was most correlated with older age at onset and bulbar onset after adjustment for all the clinical factors. CONCLUSIONS: In conclusion, vitamin D levels were not correlated to other bone markers and survival in a clinic population of ALSpatients.
Authors: B Kuraszkiewicz; H Goszczyńska; T Podsiadły-Marczykowska; M Piotrkiewicz; P Andersen; M Gromicho; J Grosskreutz; M Kuźma-Kozakiewicz; S Petri; B Stubbendorf; K Szacka; H Uysal; M de Carvalho Journal: Front Neurosci Date: 2020-05-26 Impact factor: 4.677