Masaaki Taniguchi1, Tomoaki Nakai2, Masaaki Kohta2, Hidehito Kimura2, Eiji Kohmura2. 1. Department of Neurosurgery, Kobe University Graduate School of Medicine, Hyogo, Japan. Electronic address: mtani@med.kobe-u.ac.jp. 2. Department of Neurosurgery, Kobe University Graduate School of Medicine, Hyogo, Japan.
Abstract
BACKGROUND: The etiology of hydrocephalus associated with the small- to medium-sized vestibular schwannomas is still controversial. We investigated tumor-specific factors related to the association of hydrocephalus with small- to medium-sized vestibular schwannomas. METHODS: Among the 77 patients with vestibular schwannoma smaller than 30 mm, 9 patients demonstrated associated communicating hydrocephalus. Patient medical records, radiologic data, and histopathologic specimens were reviewed retrospectively. The age of the patients, and size, mean apparent diffusion coefficient (ADC) value, and histologic features of the tumors were compared with those of patients without hydrocephalus. RESULTS: The symptoms related to hydrocephalus improved in all patients after tumor removal. Both the mean size and ADC values exhibited a statistically significant difference between the tumors with and without hydrocephalus (P < 0.01). CONCLUSIONS: The size and ADC value of the tumor were significantly related to the association with hydrocephalus. The increased tumor ADC value was considered to be the result of degenerative change and suggested the involvement of protein sloughing in the etiology of the associated hydrocephalus.
BACKGROUND: The etiology of hydrocephalus associated with the small- to medium-sized vestibular schwannomas is still controversial. We investigated tumor-specific factors related to the association of hydrocephalus with small- to medium-sized vestibular schwannomas. METHODS: Among the 77 patients with vestibular schwannoma smaller than 30 mm, 9 patients demonstrated associated communicating hydrocephalus. Patient medical records, radiologic data, and histopathologic specimens were reviewed retrospectively. The age of the patients, and size, mean apparent diffusion coefficient (ADC) value, and histologic features of the tumors were compared with those of patients without hydrocephalus. RESULTS: The symptoms related to hydrocephalus improved in all patients after tumor removal. Both the mean size and ADC values exhibited a statistically significant difference between the tumors with and without hydrocephalus (P < 0.01). CONCLUSIONS: The size and ADC value of the tumor were significantly related to the association with hydrocephalus. The increased tumor ADC value was considered to be the result of degenerative change and suggested the involvement of protein sloughing in the etiology of the associated hydrocephalus.
Authors: Paolo di Russo; Arianna Fava; Alberto Vandenbulcke; Akinori Miyakoshi; Michihiro Kohno; Alexander I Evins; Vincenzo Esposito; Roberta Morace Journal: Neurosurg Rev Date: 2020-04-07 Impact factor: 3.042