| Literature DB >> 27423028 |
Jun Yang1, Simin Yang1, Shanshan Zhou1, Dongbo Lu1, Liyan Ji1, Zhongjun Li1, Siwang Yu2, Xiangbao Meng3.
Abstract
A series of benzenesulfonamide derivatives were synthesized and evaluated for their anti-proliferative activity and interaction with tubulin. These new derivatives showed significant activities against cellular proliferative and tubulin polymerization. Compound BA-3b proved to be the most potent compound with IC50 value ranging from 0.007 to 0.036 μM against seven cancer cell lines, and three drug-resistant cancer cell lines, which indicated a promising anti-cancer agent. The target tubulin was also verified by dynamic tubulin polymerization assay and tubulin intensity assay.Entities:
Keywords: Benzodiazepine; Benzothiazepine; Benzoxazepine; Sulfonamides; Tubulin-targeting agents
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Year: 2016 PMID： 27423028 DOI： 10.1016/j.ejmech.2016.07.002
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514