Literature DB >> 27422608

Maleimide-functionalized closo-dodecaborate albumin conjugates (MID-AC): Unique ligation at cysteine and lysine residues enables efficient boron delivery to tumor for neutron capture therapy.

Shunsuke Kikuchi1, Daisuke Kanoh2, Shinichi Sato1, Yoshinori Sakurai3, Minoru Suzuki4, Hiroyuki Nakamura5.   

Abstract

Maleimide-conjugating closo-dodecaborate sodium form 5c (MID) synthesized by the nucleophilic ring-opening reaction of closo-dodecaborate-1,4-dioxane complex 2 with tetrabutylammonium (TBA) azide was found to conjugate to free SH of cysteine and lysine residues in BSA under physiological conditions, forming highly boronated BSA that showed high and selective accumulation in tumor and significant tumor growth inhibition in colon 26 tumor-bearing mice subjected to thermal neutron irradiation.
Copyright © 2016 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Albumin modification; Boron delivery system; Boron neutron capture therapy (BNCT); Closo-dodecaborate; Maleimide

Mesh：

Substances：

Year:  2016        PMID： 27422608     DOI： 10.1016/j.jconrel.2016.07.017

Source DB:  PubMed          Journal:  J Control Release        ISSN： 0168-3659            Impact factor:   9.776


  8 in total

1.  Boron neutron capture therapy using dodecaborated albumin conjugates with maleimide is effective in a rat glioma model.

Authors:  Hideki Kashiwagi; Shinji Kawabata; Kohei Yoshimura; Yusuke Fukuo; Takuya Kanemitsu; Koji Takeuchi; Ryo Hiramatsu; Kai Nishimura; Kazuki Kawai; Takushi Takata; Hiroki Tanaka; Tsubasa Watanabe; Minoru Suzuki; Shin-Ichi Miyatake; Hiroyuki Nakamura; Masahiko Wanibuchi
Journal:  Invest New Drugs       Date:  2021-11-24       Impact factor: 3.651

Review 2.  A Critical Review of Radiation Therapy: From Particle Beam Therapy (Proton, Carbon, and BNCT) to Beyond.

Authors:  Yoshitaka Matsumoto; Nobuyoshi Fukumitsu; Hitoshi Ishikawa; Kei Nakai; Hideyuki Sakurai
Journal:  J Pers Med       Date:  2021-08-23

Review 3.  Preparing (Metalla)carboranes for Nanomedicine.

Authors:  Marta Gozzi; Benedikt Schwarze; Evamarie Hey-Hawkins
Journal:  ChemMedChem       Date:  2021-03-19       Impact factor: 3.466

Review 4.  Boron delivery agents for neutron capture therapy of cancer.

Authors:  Rolf F Barth; Peng Mi; Weilian Yang
Journal:  Cancer Commun (Lond)       Date:  2018-06-19

Review 5.  Theranostics in Boron Neutron Capture Therapy.

Authors:  Wolfgang A G Sauerwein; Lucie Sancey; Evamarie Hey-Hawkins; Martin Kellert; Luigi Panza; Daniela Imperio; Marcin Balcerzyk; Giovanna Rizzo; Elisa Scalco; Ken Herrmann; PierLuigi Mauri; Antonella De Palma; Andrea Wittig
Journal:  Life (Basel)       Date:  2021-04-10

6.  Homocystamide Conjugates of Human Serum Albumin as a Platform to Prepare Bimodal Multidrug Delivery Systems for Boron Neutron Capture Therapy.

Authors:  Tatyana Popova; Maya A Dymova; Ludmila S Koroleva; Olga D Zakharova; Vladimir A Lisitskiy; Valeria I Raskolupova; Tatiana Sycheva; Sergei Taskaev; Vladimir N Silnikov; Tatyana S Godovikova
Journal:  Molecules       Date:  2021-10-29       Impact factor: 4.411

7.  Boron Neutron Capture Therapy (BNCT) Mediated by Maleimide-Functionalized Closo-Dodecaborate Albumin Conjugates (MID:BSA) for Oral Cancer: Biodistribution Studies and In Vivo BNCT in the Hamster Cheek Pouch Oral Cancer Model.

Authors:  Andrea Monti Hughes; Jessica A Goldfinger; Mónica A Palmieri; Paula Ramos; Iara S Santa Cruz; Luciana De Leo; Marcela A Garabalino; Silvia I Thorp; Paula Curotto; Emiliano C C Pozzi; Kazuki Kawai; Shinichi Sato; María E Itoiz; Verónica A Trivillin; Juan S Guidobono; Hiroyuki Nakamura; Amanda E Schwint
Journal:  Life (Basel)       Date:  2022-07-20

Review 8.  Boron neutron capture therapy: Current status and future perspectives.

Authors:  Mayya Alexandrovna Dymova; Sergey Yurjevich Taskaev; Vladimir Alexandrovich Richter; Elena Vladimirovna Kuligina
Journal:  Cancer Commun (Lond)       Date:  2020-08-17
  8 in total

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