| Literature DB >> 27421731 |
David N Soleimani-Meigooni1, Katherine E Schwetye2, Maria Reyes Angeles3, Caroline F Ryschkewitsch4, Eugene O Major4, Xin Dang5, Igor J Koralnik5, Robert E Schmidt2, David B Clifford1, F Matthew Kuhlmann3, Robert C Bucelli6.
Abstract
JC virus (JCV) is a human polyomavirus that infects the central nervous system (CNS) of immunocompromised patients. JCV granule cell neuronopathy (JCV-GCN) is caused by infection of cerebellar granule cells, causing ataxia. A 77-year-old man with iatrogenic lymphopenia presented with severe ataxia and was diagnosed with JCV-GCN. His ataxia and cerebrospinal fluid (CSF) improved with intravenous immunoglobulin, high-dose intravenous methylprednisolone, mirtazapine, and mefloquine. Interleukin-7 (IL-7) therapy reconstituted his lymphocytes and reduced his CSF JCV load. One month after IL-7 therapy, he developed worsening ataxia and CSF inflammation, which raised suspicion for immune reconstitution inflammatory syndrome. Steroids were restarted and his ataxia stabilized.Entities:
Keywords: Cerebellar ataxia; Granule cell neuronopathy; Il-7; JC virus; Lymphopenia
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Year: 2016 PMID： 27421731 PMCID： PMC5588866 DOI： 10.1007/s13365-016-0465-0
Source DB: PubMed Journal: J Neurovirol ISSN： 1355-0284 Impact factor: 2.643