Vanessa Stahl1, Florian Maier1, Martin T Freitag2, Ralf O Floca3, Moritz C Berger1, Reiner Umathum1, Mauricio Berriel Diaz4, Stephan Herzig4, Marc-André Weber5, Antonia Dimitrakopoulou-Strauss6, Kristian Rink1, Peter Bachert1, Mark E Ladd1, Armin M Nagel1,7,8. 1. Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany. 2. Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany. 3. Medical and Biological Informatics, German Cancer Research Center (DKFZ), Heidelberg, Germany. 4. Institute for Diabetes and Cancer IDC Helmholtz Center Munich and Joint Heidelberg-IDC Translational Diabetes Program, Inner Medicine 1, Heidelberg University Hospital, Neuherberg, Germany. 5. Diagnostic and Interventional Radiology, University Hospital of Heidelberg, Heidelberg, Germany. 6. Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center (DKFZ), Heidelberg, Germany. 7. Department of Diagnostic and Interventional Radiology, University Medical Center Ulm, Ulm, Germany. 8. Institute of Radiology, University Hospital Erlangen, Erlangen, Germany.
Abstract
PURPOSE: To evaluate the volume and changes of human brown adipose tissue (BAT) in vivo following exposure to cold using magnetic resonance imaging (MRI). MATERIALS AND METHODS: The clavicular region of 10 healthy volunteers was examined with a 3T MRI system. One volunteer participated twice. A cooling vest that was circulated with temperature-controlled water was used to expose each volunteer to a cold environment. Three different water temperature phases were employed: baseline (23°C, 20 min), cooling (12°C, 90 min), and a final warming phase (37°C, 30 min). Temperatures of the water in the circuit, of the body, and at the back skin of the volunteers were monitored with fiberoptic temperature probes. Applying the 2-point DIXON pulse sequence every 5 minutes, fat fraction (FF) maps were determined and evaluated over time to distinguish between brown and white adipose tissue. RESULTS: Temperature measurements showed a decrease of 3.8 ± 1.0°C of the back skin temperature, while the body temperature stayed constant at 37.2 ± 0.9°C. Focusing on the two interscapular BAT depots, a mean FF decrease of -2.9 ± 2.0%/h (P < 0.001) was detected during cold stimulation in a mean absolute volume of 1.31 ± 1.43 ml. Also, a correlation of FF decrease to back skin temperature decrease was observed in all volunteers (correlation coefficients: |r| = [0.51; 0.99]). CONCLUSION: We found that FF decreases in BAT begin immediately with mild cooling of the body and continue during long-time cooling. LEVEL OF EVIDENCE: 2 J. Magn. Reson. Imaging 2017;45:369-380.
PURPOSE: To evaluate the volume and changes of human brown adipose tissue (BAT) in vivo following exposure to cold using magnetic resonance imaging (MRI). MATERIALS AND METHODS: The clavicular region of 10 healthy volunteers was examined with a 3T MRI system. One volunteer participated twice. A cooling vest that was circulated with temperature-controlled water was used to expose each volunteer to a cold environment. Three different water temperature phases were employed: baseline (23°C, 20 min), cooling (12°C, 90 min), and a final warming phase (37°C, 30 min). Temperatures of the water in the circuit, of the body, and at the back skin of the volunteers were monitored with fiberoptic temperature probes. Applying the 2-point DIXON pulse sequence every 5 minutes, fat fraction (FF) maps were determined and evaluated over time to distinguish between brown and white adipose tissue. RESULTS: Temperature measurements showed a decrease of 3.8 ± 1.0°C of the back skin temperature, while the body temperature stayed constant at 37.2 ± 0.9°C. Focusing on the two interscapular BAT depots, a mean FF decrease of -2.9 ± 2.0%/h (P < 0.001) was detected during cold stimulation in a mean absolute volume of 1.31 ± 1.43 ml. Also, a correlation of FF decrease to back skin temperature decrease was observed in all volunteers (correlation coefficients: |r| = [0.51; 0.99]). CONCLUSION: We found that FF decreases in BAT begin immediately with mild cooling of the body and continue during long-time cooling. LEVEL OF EVIDENCE: 2 J. Magn. Reson. Imaging 2017;45:369-380.
Authors: Cora Held; Daniela Junker; Mingming Wu; Lisa Patzelt; Laura A Mengel; Christina Holzapfel; Maximilian N Diefenbach; Marcus R Makowski; Hans Hauner; Dimitrios C Karampinos Journal: Quant Imaging Med Surg Date: 2022-05
Authors: Borja Martinez-Tellez; Guillermo Sanchez-Delgado; Yolanda Garcia-Rivero; Juan M A Alcantara; Wendy D Martinez-Avila; Maria V Muñoz-Hernandez; Josune Olza; Mariëtte R Boon; Patrick C N Rensen; Jose M Llamas-Elvira; Jonatan R Ruiz Journal: Front Physiol Date: 2017-11-02 Impact factor: 4.566
Authors: D Franz; D Weidlich; F Freitag; C Holzapfel; T Drabsch; T Baum; H Eggers; A Witte; E J Rummeny; H Hauner; D C Karampinos Journal: Int J Obes (Lond) Date: 2017-08-14 Impact factor: 5.095