BACKGROUND: Diabetic retinopathy (DR) is one of the main complications in patients with diabetes and has been the leading cause of visual loss since 1990. Oxidative stress is a biological process resulting from excessive production of reactive oxygen species (ROS). This process contributes to the development of many diseases and disease complications. ROS interact with various cellular components to induce cell injury. Fortunately, there is an antioxidan t system that protects organisms against ROS. Indeed, when ROS exceed antioxidant capacity, the resulting cell injury can cause diverse physiological and pathological changes that could lead to a disease like DR. OBJECTIVE: This paper reviews the possible mechanisms of common and novel biomarkers involved in the development of DR and explores how these biomarkers could be used to monitor the damage induced by oxidative stress in DR, which is a significant complication in people with diabetes. CONCLUSION: The poor control of glucemy in pacients with DB has been shown contribute to the development of complications in eyes as DR.
BACKGROUND:Diabetic retinopathy (DR) is one of the main complications in patients with diabetes and has been the leading cause of visual loss since 1990. Oxidative stress is a biological process resulting from excessive production of reactive oxygen species (ROS). This process contributes to the development of many diseases and disease complications. ROS interact with various cellular components to induce cell injury. Fortunately, there is an antioxidan t system that protects organisms against ROS. Indeed, when ROS exceed antioxidant capacity, the resulting cell injury can cause diverse physiological and pathological changes that could lead to a disease like DR. OBJECTIVE: This paper reviews the possible mechanisms of common and novel biomarkers involved in the development of DR and explores how these biomarkers could be used to monitor the damage induced by oxidative stress in DR, which is a significant complication in people with diabetes. CONCLUSION: The poor control of glucemy in pacients with DB has been shown contribute to the development of complications in eyes as DR.
Authors: Gangaraju Rajashekhar; Ahmed Ramadan; Chandrika Abburi; Breedge Callaghan; Dmitry O Traktuev; Carmella Evans-Molina; Raj Maturi; Alon Harris; Timothy S Kern; Keith L March Journal: PLoS One Date: 2014-01-09 Impact factor: 3.240
Authors: Adolfo Daniel Rodríguez-Carrizalez; José Alberto Castellanos-González; Esaú César Martínez-Romero; Guillermo Miller-Arrevillaga; David Villa-Hernández; Pedro Pablo Hernández-Godínez; Genaro Gabriel Ortiz; Fermín Paul Pacheco-Moisés; Ernesto Germán Cardona-Muñoz; Alejandra Guillermina Miranda-Díaz Journal: J Diabetes Date: 2013-08-21 Impact factor: 4.006