Agnaldo José Lopes1, Arthur Sá Ferreira2, Evelyn Mendes Walchan3, Mauricio Santos Soares4, Priscila Santos Bunn5, Fernando Silva Guimarães6. 1. Rehabilitation Sciences Post-Graduation Program, Augusto Motta University Center, Av. Paris 72, Bonsucesso, Rio de Janeiro, Brazil. Electronic address: phel.lop@uol.com.br. 2. Rehabilitation Sciences Post-Graduation Program, Augusto Motta University Center, Av. Paris 72, Bonsucesso, Rio de Janeiro, Brazil. Electronic address: arthurde@unisuamdoc.com.br. 3. Rehabilitation Sciences Post-Graduation Program, Augusto Motta University Center, Av. Paris 72, Bonsucesso, Rio de Janeiro, Brazil. Electronic address: evelynwalchan@yahoo.com.br. 4. Admiral Adalberto Nunes Physical Education Center (Brazilian Navy), Av. Brasil, 10590, Penha, Rio de Janeiro, Brazil. Electronic address: mauricio-soares@hotmail.com. 5. Admiral Adalberto Nunes Physical Education Center (Brazilian Navy), Av. Brasil, 10590, Penha, Rio de Janeiro, Brazil. Electronic address: priscilabunn@yahoo.com.br. 6. Rehabilitation Sciences Post-Graduation Program, Augusto Motta University Center, Av. Paris 72, Bonsucesso, Rio de Janeiro, Brazil; Physical Therapy Department, Federal University of Rio de Janeiro, R. Prof. Rodolpho Paulo Rocco, 255, Cidade Universitária, Rio de Janeiro, Brazil. Electronic address: fguimaraes_pg@yahoo.com.br.
Abstract
PURPOSE: To evaluate the effects of demographics and hormonal variations on knee muscle performance in patients with acromegaly and develop explanatory models of peripheral muscle function in these individuals. METHODS: This was a cross-sectional study in which 53 acromegalics and 27 healthy subjects underwent knee isokinetic dynamometry to evaluate the peak torque value for leg extension at 75°/s (PTE75) and 240°/s (PTE240). Separate multivariable linear regression models for the prediction of PTE75 and PTE240 were tested using variables commonly used as predictors in the clinical setting and other specific variables related to acromegaly. RESULTS: The final prediction model for PTE75 (R(2)=0.888; adjusted R(2)=0.820, SE of bias=16.2Nm, p<0.001) was -0.221×growth hormone+36.791×sexmale=1-27.407×statusactive=1-0.690×age+148.071. The final prediction model for PTE240 (R(2)=0.816; adjusted R(2)=0.805, SE of bias=8.8Nm, p<0.001) was -0.174×growth hormone+12.522×sexmale=1-0.520×age+98.099. CONCLUSIONS: In acromegalics, high growth hormone levels, female gender, and older age are associated with reduced muscle strength and endurance. Additionally, active disease negatively affects peripheral muscle strength in these patients.
PURPOSE: To evaluate the effects of demographics and hormonal variations on knee muscle performance in patients with acromegaly and develop explanatory models of peripheral muscle function in these individuals. METHODS: This was a cross-sectional study in which 53 acromegalics and 27 healthy subjects underwent knee isokinetic dynamometry to evaluate the peak torque value for leg extension at 75°/s (PTE75) and 240°/s (PTE240). Separate multivariable linear regression models for the prediction of PTE75 and PTE240 were tested using variables commonly used as predictors in the clinical setting and other specific variables related to acromegaly. RESULTS: The final prediction model for PTE75 (R(2)=0.888; adjusted R(2)=0.820, SE of bias=16.2Nm, p<0.001) was -0.221×growth hormone+36.791×sexmale=1-27.407×statusactive=1-0.690×age+148.071. The final prediction model for PTE240 (R(2)=0.816; adjusted R(2)=0.805, SE of bias=8.8Nm, p<0.001) was -0.174×growth hormone+12.522×sexmale=1-0.520×age+98.099. CONCLUSIONS: In acromegalics, high growth hormone levels, female gender, and older age are associated with reduced muscle strength and endurance. Additionally, active disease negatively affects peripheral muscle strength in these patients.
Authors: Jonathan A Young; Shouan Zhu; Edward O List; Silvana Duran-Ortiz; Yosri Slama; Darlene E Berryman Journal: Front Physiol Date: 2022-05-19 Impact factor: 4.755