V Dunet1,2,3, J Deverdun4,2,5,6, C Charroud4,2,7,8, E Le Bars4,2, F Molino5,9, S Menjot de Champfleur10, F Maury11, M Charif11, X Ayrignac11, P Labauge11, G Castelnovo12, F Pinna4,11,2, A Bonafe4,2,13, C Geny11,14,15, N Menjot de Champfleur4,2,16,13. 1. From the Departments of Neuroradiology (V.D., J.D., C.C., E.L.B., F.P, A.B., N.M.d.C.) vincent.dunet@chuv.ch. 2. Institut d'Imagerie Fonctionnelle Humaine, I2FH (V.D., J.D., C.C., E.L.B., F.P., A.B., N.M.d.C.), Hôpital Gui de Chauliac, Centre Hospitalier Régional Universitaire de Montpellier, Montpellier, France. 3. Department of Diagnostic and Interventional Radiology (V.D), Lausanne University Hospital, Lausanne, Switzerland. 4. From the Departments of Neuroradiology (V.D., J.D., C.C., E.L.B., F.P, A.B., N.M.d.C.). 5. Laboratoire Charles Coulomb (J.D., F.Molino), Centre National de la Recherche Scientifique Unite Mixte de Recherche 5221, Montpellier University, Montpellier, France. 6. Intrasense (J.D.), Montpellier, France. 7. Neuropsychiatry: Epidemiological and Clinical Research (C.C.), Institut National de la Santé et de la Recherche Médicale, U1061, Montpellier University, La Colombiere Hospital, Montpellier, France. 8. Institut National de la Santé et de la Recherche Médicale (C.C.), U1198, Montpellier University, Montpellier, France. 9. Institut de Genomique Fonctionnelle (F.Molino), UMR 5203, Institut National de la Santé et de la Recherche Médicale, U661, Montpellier University, Montpellier, France. 10. Clinique du Parc (S.M.d.C.), Service d'imagerie, Castenau-Le-Lez, France. 11. Neurology (F.Maury, M.C., X.A., P.L., F.P., C.G.), Montpellier University Hospital Center, Gui de Chauliac Hospital, Montpellier, France. 12. Departments of Neurology (G.C.). 13. Team "Plasticity of Central Nervous System, Stem Cells and Glial Tumors" (A.B., N.M.d.C,), U1051, Institut of Neurosciences of Montpellier, Saint Eloi Hospital, Montpellier, France. 14. EuroMov (C.G.), Montpellier, France. 15. Movement to Health (C.G.), Montpellier University, Montpellier, France. 16. Medical Imaging (N.M.d.C.), Caremeau University Hospital Center, Nimes, France.
Abstract
BACKGROUND AND PURPOSE: Patients with vascular parkinsonism have higher cognitive decline and more basal ganglia lesions. We aimed to evaluate the relationship of cognitive impairment with functional connectivity between the basal ganglia and cingulate cortex in vascular parkinsonism. MATERIALS AND METHODS: Thirty patients (8 with vascular parkinsonism and 22 with Parkinson disease) and 23 controls were enrolled. The Mattis Dementia Rating Scale and the Stroop Task were used to assess cognitive decline. MR imaging examinations included T1-MPRAGE, FLAIR, and resting-state fMRI sequences. MPRAGE was segmented to obtain basal ganglia and cingulate cortex volumes. FLAIR was segmented to obtain white matter hyperintensity lesion volume. Resting-state fMRI sequences were used to compare basal ganglia functional connectivity with the cingulate cortex between patients and controls. RESULTS: Patients with vascular parkinsonism exhibited impaired attention, resistance to interference, and inhibitory control and an increased number of errors on the Stroop Task. They also had higher caudate nucleus and white matter hyperintensity lesion volumes, which were positively correlated (ρ = 0.75, P < .0001). Caudate nucleus functional connectivity with the perigenual anterior cingulate cortex was increased in patients with vascular parkinsonism compared with controls and patients with Parkinson disease, and it was positively correlated with the caudate nucleus volume (ρ = 0.44, P = .016). Caudate nucleus functional connectivity with the posterior cingulate cortex was decreased in patients with vascular parkinsonism compared with controls and negatively correlated with the number of errors on the Stroop test (ρ = -0.51, P = .0003). CONCLUSIONS: In patients with vascular parkinsonism, cognitive decline could be related to changes of caudate nucleus functional connectivity with the cingulate cortex at resting-state, which may be induced by ischemia-related remodelling.
BACKGROUND AND PURPOSE:Patients with vascular parkinsonism have higher cognitive decline and more basal ganglia lesions. We aimed to evaluate the relationship of cognitive impairment with functional connectivity between the basal ganglia and cingulate cortex in vascular parkinsonism. MATERIALS AND METHODS: Thirty patients (8 with vascular parkinsonism and 22 with Parkinson disease) and 23 controls were enrolled. The Mattis Dementia Rating Scale and the Stroop Task were used to assess cognitive decline. MR imaging examinations included T1-MPRAGE, FLAIR, and resting-state fMRI sequences. MPRAGE was segmented to obtain basal ganglia and cingulate cortex volumes. FLAIR was segmented to obtain white matter hyperintensity lesion volume. Resting-state fMRI sequences were used to compare basal ganglia functional connectivity with the cingulate cortex between patients and controls. RESULTS:Patients with vascular parkinsonism exhibited impaired attention, resistance to interference, and inhibitory control and an increased number of errors on the Stroop Task. They also had higher caudate nucleus and white matter hyperintensity lesion volumes, which were positively correlated (ρ = 0.75, P < .0001). Caudate nucleus functional connectivity with the perigenual anterior cingulate cortex was increased in patients with vascular parkinsonism compared with controls and patients with Parkinson disease, and it was positively correlated with the caudate nucleus volume (ρ = 0.44, P = .016). Caudate nucleus functional connectivity with the posterior cingulate cortex was decreased in patients with vascular parkinsonism compared with controls and negatively correlated with the number of errors on the Stroop test (ρ = -0.51, P = .0003). CONCLUSIONS: In patients with vascular parkinsonism, cognitive decline could be related to changes of caudate nucleus functional connectivity with the cingulate cortex at resting-state, which may be induced by ischemia-related remodelling.
Authors: Tom Eichele; Stefan Debener; Vince D Calhoun; Karsten Specht; Andreas K Engel; Kenneth Hugdahl; D Yves von Cramon; Markus Ullsperger Journal: Proc Natl Acad Sci U S A Date: 2008-04-21 Impact factor: 11.205
Authors: S A Molloy; E N Rowan; J T O'Brien; I G McKeith; K Wesnes; D J Burn Journal: J Neurol Neurosurg Psychiatry Date: 2006-09-04 Impact factor: 10.154
Authors: Vincent Dunet; Jeremy Deverdun; Celine Charroud; Emmanuelle Le Bars; Francois Molino; Sophie Menjot de Champfleur; Florence Maury; Mahmoud Charif; Xavier Ayrignac; Pierre Labauge; Giovanni Castelnovo; Frederic Pinna; Alain Bonafe; Christian Geny; Nicolas Menjot de Champfleur Journal: J Neurol Date: 2017-07-01 Impact factor: 4.849