Literature DB >> 27417989

Successful treatment of refractory midgut bleeding with ocreotide and corticosteroids in a dialysis patient with suspected sarcoidosis.

Nestor Velasco1, Toufeeq Imtiaz1, Amir Ali Shah1, Anastasios Koulaouzidis2.   

Abstract

We present a case of severe and recurrent small-bowel bleeding, due to multiple intestinal angiodysplasias, in a female patient with chronic renal failure due to suspected sarcoidosis. Over the years, she required numerous admissions and >200 units of blood for symptomatic anaemia. However, following a small-bowel capsule endoscopy that revealed several small-bowel angiectasis, she was treated successfully with octreotide and corticosteroids. Her transfusion requirements and hospital admissions were reduced drastically. Moreover, hypercalcaemia and liver function tests also normalised after treatment and double-balloon enteroscopy confirmed the complete resolution of these angiodysplasias. This case presentation confirms the usefulness of octreotide in the management of small-bowel angiodysplasias in dialysis patients and highlights the additional benefit of corticosteroids in portal hypertension due to suspected sarcoidosis. 2016 BMJ Publishing Group Ltd.

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Year:  2016        PMID: 27417989      PMCID: PMC4956989          DOI: 10.1136/bcr-2016-215513

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  11 in total

1.  Abnormal von Willebrand factor in bleeding angiodysplasias of the digestive tract.

Authors:  A Veyradier; A Balian; M Wolf; V Giraud; S Montembault; B Obert; I Dagher; J C Chaput; D Meyer; S Naveau
Journal:  Gastroenterology       Date:  2001-02       Impact factor: 22.682

2.  Long-acting somatostatin analogues provide significant beneficial effect in patients with refractory small bowel angiodysplasia: Results from a proof of concept open label mono-centre trial.

Authors:  Grainne Holleran; Barry Hall; Niall Breslin; Deirdre McNamara
Journal:  United European Gastroenterol J       Date:  2015-11-05       Impact factor: 4.623

3.  Angiodysplasia. Natural history and efficacy of therapeutic interventions.

Authors:  J M Richter; M R Christensen; G A Colditz; N S Nishioka
Journal:  Dig Dis Sci       Date:  1989-10       Impact factor: 3.199

4.  Long-acting octreotide as rescue therapy in chronic bleeding from gastrointestinal angiodysplasia.

Authors:  G Scaglione; L Pietrini; F Russo; M R Franco; I Sorrentini
Journal:  Aliment Pharmacol Ther       Date:  2007-09-15       Impact factor: 8.171

5.  Long-acting somatostatin analogues decrease blood transfusion requirements in patients with refractory gastrointestinal bleeding associated with angiodysplasia.

Authors:  C Bon; T Aparicio; M Vincent; M Mavros; B Bejou; J-J Raynaud; E Zampeli; G Airinei; D Sautereau; R Benamouzig; S Michopoulos
Journal:  Aliment Pharmacol Ther       Date:  2012-07-26       Impact factor: 8.171

6.  Long acting release-octreotide as "rescue" therapy to control angiodysplasia bleeding: A retrospective study of 98 cases.

Authors:  Gerardo Nardone; Debora Compare; Carmelo Scarpignato; Alba Rocco
Journal:  Dig Liver Dis       Date:  2014-06-02       Impact factor: 4.088

7.  Presence of IGF-I in human midgut carcinoid tumours--an autocrine regulator of carcinoid tumour growth?

Authors:  O Nilsson; B Wängberg; E Theodorsson; A Skottner; H Ahlman
Journal:  Int J Cancer       Date:  1992-05-08       Impact factor: 7.396

8.  Use of small bowel capsule endoscopy in patients with chronic kidney disease: experience from a University Referral Center.

Authors:  Emily Docherty; Anastasios Koulaouzidis; Sarah Douglas; John N Plevris
Journal:  Ann Gastroenterol       Date:  2015 Jan-Mar

Review 9.  Advances in the diagnosis and treatment of sarcoidosis.

Authors:  Marc A Judson
Journal:  F1000Prime Rep       Date:  2014-10-01

Review 10.  Corticosteroids and risk of gastrointestinal bleeding: a systematic review and meta-analysis.

Authors:  Sigrid Narum; Tone Westergren; Marianne Klemp
Journal:  BMJ Open       Date:  2014-05-15       Impact factor: 2.692

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  1 in total

Review 1.  Role of octreotide in small bowel bleeding.

Authors:  Anwar Khedr; Esraa Elaraby Mahmoud; Noura Attallah; Mikael Mir; Sydney Boike; Ibtisam Rauf; Abbas B Jama; Hisham Mushtaq; Salim Surani; Syed A Khan
Journal:  World J Clin Cases       Date:  2022-09-16       Impact factor: 1.534

  1 in total

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