Literature DB >> 27417710

Glutamate release and uptake processes are altered in a new mouse model of amyotrophic lateral sclerosis.

V V Grigoriev1, A D Efimova2, A A Ustyugov1, V P Shevchenko3, S O Bachurin1, N F Myasoedov3.   

Abstract

In this paper, we showed that in the cortex of mice expressing an abberant form of FUS protein that model amyotrophic lateral sclerosis (ALS), the processes of KCl-induced and basal [(3)H]glutamate release and uptake are altered at the presymptomatic stage as compared to the non-transgenic littermates. The change in these three parameters in transgenic animals causes excitotoxicity, which, in turn, may lead to massive loss of motor neurons and the onset of ALS symptoms.

Entities:  

Mesh：

Substances：

Year:  2016        PMID： 27417710     DOI： 10.1134/S1607672916030017

Source DB:  PubMed          Journal:  Dokl Biochem Biophys        ISSN： 1607-6729            Impact factor:   0.788


  8 in total

1.  [New aspects of the pathogenesis of lateral amyotrophic sclerosis].

Authors:  V I Skvortsova; S O Bachurin; O D Razinskaia; A P Smirnov; E A Kovrazhkina; K I Pochigaeva; N N Ninkina; T A Shelkovnikova; A A Ustiugov
Journal:  Zh Nevrol Psikhiatr Im S S Korsakova       Date:  2011

Review 2.  The role of excitotoxicity in the pathogenesis of amyotrophic lateral sclerosis.

Authors:  L Van Den Bosch; P Van Damme; E Bogaert; W Robberecht
Journal:  Biochim Biophys Acta       Date:  2006-05-17

Review 3.  [Modeling of lateral amyotrophic sclerosis: a transgenic method].

Authors:  S O Bachurin; N N Ninkina; T V Tarasova; T V Shelkovnikova; E A Kovrazhkina; A P Smirnov; O D Razinskaia; V I Skvortsova
Journal:  Zh Nevrol Psikhiatr Im S S Korsakova       Date:  2013

4.  Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis.

Authors:  J D Rothstein; M Van Kammen; A I Levey; L J Martin; R W Kuncl
Journal:  Ann Neurol       Date:  1995-07       Impact factor: 10.422

5.  Abnormal exocytotic release of glutamate in a mouse model of amyotrophic lateral sclerosis.

Authors:  Marco Milanese; Simona Zappettini; Franco Onofri; Laura Musazzi; Daniela Tardito; Tiziana Bonifacino; Mirko Messa; Giorgio Racagni; Cesare Usai; Fabio Benfenati; Maurizio Popoli; Giambattista Bonanno
Journal:  J Neurochem       Date:  2011-01-20       Impact factor: 5.372

Review 6.  Molecular and cellular pathways of neurodegeneration in motor neurone disease.

Authors:  P J Shaw
Journal:  J Neurol Neurosurg Psychiatry       Date:  2005-08       Impact factor: 10.154

7.  In vitro neurotoxic properties and excitatory aminoacids concentration in the cerebrospinal fluid of amyotrophic lateral sclerosis patients. Relationship with the degree of certainty of disease diagnoses.

Authors:  M L Fiszman; K C Ricart; A Latini; G Rodríguez; R E P Sica
Journal:  Acta Neurol Scand       Date:  2009-10-05       Impact factor: 3.209

8.  Fused in sarcoma (FUS) protein lacking nuclear localization signal (NLS) and major RNA binding motifs triggers proteinopathy and severe motor phenotype in transgenic mice.

Authors:  Tatyana A Shelkovnikova; Owen M Peters; Alexey V Deykin; Natalie Connor-Robson; Hannah Robinson; Alexey A Ustyugov; Sergey O Bachurin; Tatyana G Ermolkevich; Igor L Goldman; Elena R Sadchikova; Elena A Kovrazhkina; Veronica I Skvortsova; Shuo-Chien Ling; Sandrine Da Cruz; Philippe A Parone; Vladimir L Buchman; Natalia N Ninkina
Journal:  J Biol Chem       Date:  2013-07-18       Impact factor: 5.157
  8 in total
  1 in total

Review 1.  RNA Editing: A New Therapeutic Target in Amyotrophic Lateral Sclerosis and Other Neurological Diseases.

Authors:  Takashi Hosaka; Hiroshi Tsuji; Shin Kwak
Journal:  Int J Mol Sci       Date:  2021-10-11       Impact factor: 5.923
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.