Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Metronidazole Metabolism in Neonates and the Interplay Between Ontogeny and Genetic Variation.

Literature DB >> 27417511

Metronidazole Metabolism in Neonates and the Interplay Between Ontogeny and Genetic Variation.

Laura A Wang¹, Daniel Gonzalez², J Steven Leeder^3,4,5, Rachel F Tyndale⁶, Robin E Pearce^3,4,5, Daniel K Benjamin^1,7, Gregory L Kearns⁸, Michael Cohen-Wolkowiez^1,7.

Abstract

Entities: Chemical

Keywords: metabolism; metronidazole; neonates; pharmacokinetics

Mesh：

Substances：

Year: 2016 PMID： 27417511 PMCID： PMC5233579 DOI： 10.1002/jcph.797

Source DB: PubMed Journal: J Clin Pharmacol ISSN： 0091-2700 Impact factor: 2.860

× No keyword cloud information.

22 in total

1. Ethnic variation in CYP2A6 and association of genetically slow nicotine metabolism and smoking in adult Caucasians.

Authors: Kerri A Schoedel; Ewa B Hoffmann; Yushu Rao; Edward M Sellers; Rachel F Tyndale
Journal: Pharmacogenetics Date: 2004-09

2. CYP2A6 genotyping methods and strategies using real-time and end point PCR platforms.

Authors: Catherine A Wassenaar; Qian Zhou; Rachel F Tyndale
Journal: Pharmacogenomics Date: 2015-12-15 Impact factor: 2.533

3. A novel CYP2A6 allele, CYP2A6*23, impairs enzyme function in vitro and in vivo and decreases smoking in a population of Black-African descent.

Authors: Man Ki Ho; Jill C Mwenifumbo; Bin Zhao; Elizabeth M J Gillam; Rachel F Tyndale
Journal: Pharmacogenet Genomics Date: 2008-01 Impact factor: 2.089

4. A novel polymorphism of human CYP2A6 gene CYP2A6*17 has an amino acid substitution (V365M) that decreases enzymatic activity in vitro and in vivo.

Authors: Tatsuki Fukami; Miki Nakajima; Ryoko Yoshida; Yuki Tsuchiya; Yuto Fujiki; Miki Katoh; Howard L McLeod; Tsuyoshi Yokoi
Journal: Clin Pharmacol Ther Date: 2004-12 Impact factor: 6.875

Review 5. Pharmacokinetics and pharmacodynamics of the nitroimidazole antimicrobials.

Authors: K C Lamp; C D Freeman; N E Klutman; M K Lacy
Journal: Clin Pharmacokinet Date: 1999-05 Impact factor: 6.447

6. A comparison of hepatic cytochrome P450 protein expression between infancy and postinfancy.

Authors: T Tateishi; H Nakura; M Asoh; M Watanabe; M Tanaka; T Kumai; S Takashima; S Imaoka; Y Funae; Y Yabusaki; T Kamataki; S Kobayashi
Journal: Life Sci Date: 1997 Impact factor: 5.037

7. Comprehensive evaluation of variability in nicotine metabolism and CYP2A6 polymorphic alleles in four ethnic populations.

Authors: Miki Nakajima; Tatsuki Fukami; Hiroyuki Yamanaka; Eriko Higashi; Haruko Sakai; Ryoko Yoshida; Jun-Tack Kwon; Howard L McLeod; Tsuyoshi Yokoi
Journal: Clin Pharmacol Ther Date: 2006-09 Impact factor: 6.875

Review 2. The Ontogeny of UDP-glucuronosyltransferase Enzymes, Recommendations for Future Profiling Studies and Application Through Physiologically Based Pharmacokinetic Modelling.

Authors: Justine Badée; Stephen Fowler; Saskia N de Wildt; Abby C Collier; Stephan Schmidt; Neil Parrott
Journal: Clin Pharmacokinet Date: 2019-02 Impact factor: 6.447

2 in total

Metronidazole Metabolism in Neonates and the Interplay Between Ontogeny and Genetic Variation.

1. Ethnic variation in CYP2A6 and association of genetically slow nicotine metabolism and smoking in adult Caucasians.

2. CYP2A6 genotyping methods and strategies using real-time and end point PCR platforms.

3. A novel CYP2A6 allele, CYP2A6*23, impairs enzyme function in vitro and in vivo and decreases smoking in a population of Black-African descent.

4. A novel polymorphism of human CYP2A6 gene CYP2A6*17 has an amino acid substitution (V365M) that decreases enzymatic activity in vitro and in vivo.

Review 5. Pharmacokinetics and pharmacodynamics of the nitroimidazole antimicrobials.

6. A comparison of hepatic cytochrome P450 protein expression between infancy and postinfancy.

7. Comprehensive evaluation of variability in nicotine metabolism and CYP2A6 polymorphic alleles in four ethnic populations.

Review 8. Bacteremia due to anaerobic bacteria in newborns.

Review 9. The ontogeny of drug metabolism enzymes and implications for adverse drug events.

10. CYP2A6 genotype but not age determines cotinine half-life in infants and children.

1. Evaluating metronidazole as a novel, safe CYP2A6 phenotyping probe in healthy adults.

Review 2. The Ontogeny of UDP-glucuronosyltransferase Enzymes, Recommendations for Future Profiling Studies and Application Through Physiologically Based Pharmacokinetic Modelling.