OBJECTIVE: The aims of this study were to evaluate the reproducibility of the Gleason grading system and to compare its interobserver variability with the novel Gleason grade grouping proposal using a large sample volume. MATERIALS AND METHODS: In total, 407 pathology slides of prostate needle biopsies from 34 consecutive patients with prostate cancer were re-evaluated. The International Society of Urological Pathology 2005 modified Gleason grading system with Epstein's modification was used. Two pathologists, blind to each other and to the initial pathology report, performed the pathological evaluation. To determine interobserver concordance, the kappa (κ) coefficient test was used. RESULTS: Pathologist 1 and pathologist 2 detected a tumor in 202 and 231 cores, respectively (p < 0.001). The two pathologists disagreed on the presence of a tumor in 31 cores. Of these 31 cores, 74% (n = 23/31) were Gleason pattern 3. The mean length of the cancer foci in these 31 disputed cores was 1.54 ± 0.8 mm. Concordance rates between the two observers for primary and secondary Gleason patterns were 63.96% (κ = 0.34) and 63.45% (κ = 0.37), respectively. Concordance with respect to the Gleason sum was 57.9% (κ = 0.43). When the Gleason scores were classified into the novel Gleason grade grouping, concordance was found to be 51.7% (κ = 0.39). CONCLUSIONS: The agreement between observers on the Gleason sum was moderate. The novel Gleason grade grouping did not improve interobserver agreement. Further studies are needed to confirm these results on interobserver variability.
OBJECTIVE: The aims of this study were to evaluate the reproducibility of the Gleason grading system and to compare its interobserver variability with the novel Gleason grade grouping proposal using a large sample volume. MATERIALS AND METHODS: In total, 407 pathology slides of prostate needle biopsies from 34 consecutive patients with prostate cancer were re-evaluated. The International Society of Urological Pathology 2005 modified Gleason grading system with Epstein's modification was used. Two pathologists, blind to each other and to the initial pathology report, performed the pathological evaluation. To determine interobserver concordance, the kappa (κ) coefficient test was used. RESULTS: Pathologist 1 and pathologist 2 detected a tumor in 202 and 231 cores, respectively (p < 0.001). The two pathologists disagreed on the presence of a tumor in 31 cores. Of these 31 cores, 74% (n = 23/31) were Gleason pattern 3. The mean length of the cancer foci in these 31 disputed cores was 1.54 ± 0.8 mm. Concordance rates between the two observers for primary and secondary Gleason patterns were 63.96% (κ = 0.34) and 63.45% (κ = 0.37), respectively. Concordance with respect to the Gleason sum was 57.9% (κ = 0.43). When the Gleason scores were classified into the novel Gleason grade grouping, concordance was found to be 51.7% (κ = 0.39). CONCLUSIONS: The agreement between observers on the Gleason sum was moderate. The novel Gleason grade grouping did not improve interobserver agreement. Further studies are needed to confirm these results on interobserver variability.
Authors: Kevin Sandeman; Sami Blom; Ville Koponen; Anniina Manninen; Juuso Juhila; Antti Rannikko; Tuomas Ropponen; Tuomas Mirtti Journal: Diagnostics (Basel) Date: 2022-04-20
Authors: Carlo Andrea Bravi; Emily Vertosick; Amy Tin; Simone Scuderi; Giuseppe Fallara; Giuseppe Rosiello; Elio Mazzone; Marco Bandini; Giorgio Gandaglia; Nicola Fossati; Massimo Freschi; Rodolfo Montironi; Alberto Briganti; Francesco Montorsi; Andrew Vickers Journal: Eur Urol Oncol Date: 2018-11-24
Authors: Patrick Leo; Sacheth Chandramouli; Xavier Farré; Robin Elliott; Andrew Janowczyk; Kaustav Bera; Pingfu Fu; Nafiseh Janaki; Ayah El-Fahmawi; Mohammed Shahait; Jessica Kim; David Lee; Kosj Yamoah; Timothy R Rebbeck; Francesca Khani; Brian D Robinson; Natalie N C Shih; Michael Feldman; Sanjay Gupta; Jesse McKenney; Priti Lal; Anant Madabhushi Journal: Eur Urol Focus Date: 2021-04-30
Authors: Tanja Spethmann; Lukas Clemens Böckelmann; Vera Labitzky; Ann-Kristin Ahlers; Jennifer Schröder-Schwarz; Sarah Bonk; Ronald Simon; Guido Sauter; Hartwig Huland; Robert Kypta; Udo Schumacher; Tobias Lange Journal: Mol Oncol Date: 2021-02-17 Impact factor: 6.603