Luis Eduardo Almeida1, Sean Pierce1, Joseph Zacharias1, William Cullinan2, Lucia Noronha3, Marcia Olandoski3, Vinicius Tramontina4, Carla Loreto5, Rosalia Leonardi6. 1. a Oral Sciences Department, Oral Surgery , School of Dentistry, Marquette University , Milwaukee , WI , USA. 2. b Biomedical Sciences , College of Health Sciences, Marquette University , Milwaukee , WI , USA. 3. c School of Health and Biosciences , Pontifícia Universidade Católica do Paraná , Curitiba , Brazil. 4. d Periodontics Department, School of Dentistry , Pontifícia Universidade Católica do Paraná , Curitiba , Parana , Brazil. 5. e Department of Biomedical and Biotechnological Sciences, Human Anatomy and Histology Section , University of Catania , Catania , Italy. 6. f Department of Surgical Sciences , University of Catania , Catania , Italy.
Abstract
PURPOSE: Interleukin-1 beta (IL-1β) is a cytokine that participates in the regulation of immune responses and inflammatory reactions. It is hypothesized that IL-1 levels may be elevated in patients suffering from temporomandibular joint dysfunction. The purpose of this study was to determine the association of IL-1β expression with TMD using an immunohistochemical approach to evaluate the joint disc. MATERIALS AND METHODS: A total of 39 human temporomandibular joint disc samples were collected, with 31 samples in the test group. Nineteen of the test group samples were from discs of patients with anterior disc displacement with reduction, and 12 of the samples were from patients with anterior disc displacement without reduction. Eight control samples were used in the control group. The samples were immunostained and evaluated on both quantity and intensity of staining. RESULTS: There was a statistically significant difference (p < 0.05) between the control and test groups for both quantity and intensity of staining. CONCLUSION: IL-1β plays a role in the inflammatory process and degradation of TMJ discs in patients with TMJ dysfunctions.
PURPOSE:Interleukin-1 beta (IL-1β) is a cytokine that participates in the regulation of immune responses and inflammatory reactions. It is hypothesized that IL-1 levels may be elevated in patients suffering from temporomandibular joint dysfunction. The purpose of this study was to determine the association of IL-1β expression with TMD using an immunohistochemical approach to evaluate the joint disc. MATERIALS AND METHODS: A total of 39 human temporomandibular joint disc samples were collected, with 31 samples in the test group. Nineteen of the test group samples were from discs of patients with anterior disc displacement with reduction, and 12 of the samples were from patients with anterior disc displacement without reduction. Eight control samples were used in the control group. The samples were immunostained and evaluated on both quantity and intensity of staining. RESULTS: There was a statistically significant difference (p < 0.05) between the control and test groups for both quantity and intensity of staining. CONCLUSION:IL-1β plays a role in the inflammatory process and degradation of TMJ discs in patients with TMJ dysfunctions.
Authors: Natália Dos Reis Ferreira; Carolina Kaminski Sanz; Aline Raybolt; Cláudia Maria Pereira; Marcos Fabio DosSantos Journal: Front Pain Res (Lausanne) Date: 2022-03-18