Fátima Roque1,2,3, António Teixeira-Rodrigues1,4, Luiza Breitenfeld2, Maria Piñeiro-Lamas5, Adolfo Figueiras5,6, Maria Teresa Herdeiro1,7. 1. Department of Medical Sciences & Institute for Biomedicine - iBiMED, University of Aveiro, 3810-193 Aveiro, Portugal. 2. Health Sciences Research Centre, University of Beira Interior (Centro de Investigação em Ciências da Saúde - CICS/UBI), 6200-506 Covilhã, Portugal. 3. Research Unit for Inland Development, Polytechnic of Guarda (Unidade de Investigação para o Desenvolvimento do Interior - UDI/IPG), 6300-559 Guarda, Portugal. 4. Faculty of Pharmacy, University of Coimbra (Faculdade de Farmácia da Universidade de Coimbra - FFUC), 3000-548 Coimbra, Portugal. 5. Consortium for Biomedical Research in Epidemiology & Public Health (CIBER enEpidemiología y Salud Pública - CIBERESP), Spain. 6. Department of Preventive Medicine & Public Health, University of Santiago de Compostela, Santiago de Compostela, Spain. 7. Higher Polytechnic & University Education Co-operative (Cooperativa de Ensino Superior Politécnico e Universitário - CESPU), Institute for Advanced Research & Training in Health Sciences & Technologies, 4585-116 Gandra, Portugal.
Abstract
AIM: To decrease population antibiotic use through an educational intervention targeting primary care physicians' and community pharmacists' attitudes and knowledge. METHODS: We designed a pragmatic cluster-randomized trial covering all National Health System primary care physicians and all community pharmacists' in a region in the north of Portugal. The study protocol was registered on ClinicalTrials.gov (identifier: NCT02173509). RESULTS: After adjustment for baseline values and comparison with the control group, the intervention was associated with a significant reduction in overall antibiotic use in the year following the intervention. The effect was most marked for tetracyclines, macrolides and cephalosporins. No statistically significant differences were observed for fluoroquinolone consumption. CONCLUSION: Multifaceted interventions involving physicians, pharmacists and general public proved effective in reducing antibiotic consumption in the population.
RCT Entities:
AIM: To decrease population antibiotic use through an educational intervention targeting primary care physicians' and community pharmacists' attitudes and knowledge. METHODS: We designed a pragmatic cluster-randomized trial covering all National Health System primary care physicians and all community pharmacists' in a region in the north of Portugal. The study protocol was registered on ClinicalTrials.gov (identifier: NCT02173509). RESULTS: After adjustment for baseline values and comparison with the control group, the intervention was associated with a significant reduction in overall antibiotic use in the year following the intervention. The effect was most marked for tetracyclines, macrolides and cephalosporins. No statistically significant differences were observed for fluoroquinolone consumption. CONCLUSION: Multifaceted interventions involving physicians, pharmacists and general public proved effective in reducing antibiotic consumption in the population.
Entities:
Keywords:
antibiotic consumption; antibiotic policies; community pharmacists; educational interventions; microbial resistance; primary care physicians
Authors: Louise Forsetlund; Mary Ann O'Brien; Lisa Forsén; Liv Merete Reinar; Mbah P Okwen; Tanya Horsley; Christopher J Rose Journal: Cochrane Database Syst Rev Date: 2021-09-15
Authors: Adolfo Figueiras; Paula López-Vázquez; Cristian Gonzalez-Gonzalez; Juan Manuel Vázquez-Lago; María Piñeiro-Lamas; Ana López-Durán; Coro Sánchez; María Teresa Herdeiro; Maruxa Zapata-Cachafeiro Journal: Antimicrob Resist Infect Control Date: 2020-12-07 Impact factor: 4.887
Authors: António Teixeira Rodrigues; João C F Nunes; Marta Estrela; Adolfo Figueiras; Fátima Roque; Maria Teresa Herdeiro Journal: Antibiotics (Basel) Date: 2021-05-25
Authors: Maarten Lambert; Chloé C H Smit; Stijn De Vos; Ria Benko; Carl Llor; W John Paget; Kathryn Briant; Lisa Pont; Liset Van Dijk; Katja Taxis Journal: Br J Clin Pharmacol Date: 2022-02-28 Impact factor: 3.716