Literature DB >> 27414262

Histologic transformation of chronic lymphocytic leukemia/small lymphocytic lymphoma.

Rose Lou Marie C Agbay1, Nitin Jain2, Sanam Loghavi1, L Jeffrey Medeiros1, Joseph D Khoury3.   

Abstract

Although generally considered a clinically indolent neoplasm, CLL/SLL may undergo transformation to a clinically aggressive lymphoma. The most common form of transformation, to DLBCL, is also known as Richter syndrome. Transformation determines the course of the disease and is associated with unfavorable patient outcome. Precise detection of transformation and identification of predictive biomarkers and specific molecular pathways implicated in the pathobiology of transformation in CLL/SLL will enable personalized therapeutic approach and provide potential avenues for improving the clinical outcome of patients. In this review, we present an overview of the pathologic features, risk factors, and pathogenic mechanisms of CLL/SLL transformation. Am. J. Hematol. 91:1036-1043, 2016.
© 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

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Year:  2016        PMID： 27414262     DOI： 10.1002/ajh.24473

Source DB:  PubMed          Journal:  Am J Hematol        ISSN： 0361-8609            Impact factor:   10.047


  7 in total

1.  Chronic Lymphocytic Leukemia Progression Diagnosis with Intrinsic Cellular Patterns via Unsupervised Clustering.

Authors:  Pingjun Chen; Siba El Hussein; Fuyong Xing; Muhammad Aminu; Aparajith Kannapiran; John D Hazle; L Jeffrey Medeiros; Ignacio I Wistuba; David Jaffray; Joseph D Khoury; Jia Wu
Journal:  Cancers (Basel)       Date:  2022-05-13       Impact factor: 6.575

2.  B-cell lymphomas with discordance between pathological features and clinical behavior.

Authors:  Laurence de Leval; Christiane Copie-Bergman; Andreas Rosenwald; Lisa Rimsza; Stefania Pittaluga; Bettina Bisig; Stefan Dirnhofer; Fabio Facchetti; Stefano Pileri; Falko Fend; Andrew Wotherspoon
Journal:  Virchows Arch       Date:  2017-06-01       Impact factor: 4.064

3.  Artificial intelligence strategy integrating morphologic and architectural biomarkers provides robust diagnostic accuracy for disease progression in chronic lymphocytic leukemia.

Authors:  Siba El Hussein; Pingjun Chen; L Jeffrey Medeiros; Ignacio I Wistuba; David Jaffray; Jia Wu; Joseph D Khoury
Journal:  J Pathol       Date:  2021-10-25       Impact factor: 9.883

4.  Prostatic-Like Syndrome in a Woman with Chronic Lymphocytic Leukemia: Sequential Kinase Inhibitor Therapy.

Authors:  Diego Velasco-Rodríguez; Miguel Piris-Villaespesa; Carmen Soteras; Ana Vallés; José Antonio García-Marco; José Antonio García-Vela
Journal:  Case Rep Hematol       Date:  2017-07-02

Review 5.  Biology and Treatment of Richter Transformation.

Authors:  Adalgisa Condoluci; Davide Rossi
Journal:  Front Oncol       Date:  2022-03-22       Impact factor: 6.244

6.  Second lung malignancy and Richter syndrome in chronic lymphocytic leukemia: case report and literature review.

Authors:  Ghassen Soussi; Selsabil Daboussi; Samira Mhamdi; Zied Moatemri; Hela Ghedira; Chiraz Aichaouia; Mohsen Khadhraoui; Faouzi El Mezni; Rezaik Cheikh
Journal:  Multidiscip Respir Med       Date:  2017-09-29

7.  An Unusual Presentation of Richter's Transformation of Chronic Lymphocytic Leukemia in Liver and Lung on 18F-Labeled Fluoro-2-Deoxyglucose Positron Emission Tomography/Computed Tomography.

Authors:  Apurva Sood; Ashwin Singh Parihar; Deepesh Lad; Rajender Kumar; Harmandeep Singh; Bhagwant Rai Mittal
Journal:  Indian J Nucl Med       Date:  2019-12-31
  7 in total

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